Comparative biomechanics of thick filaments and thin filaments with functional consequences for muscle contraction.

Journal of Biomedicine & Biotechnology
Mark S MillerJim O Vigoreaux

Abstract

The scaffold of striated muscle is predominantly comprised of myosin and actin polymers known as thick filaments and thin filaments, respectively. The roles these filaments play in muscle contraction are well known, but the extent to which variations in filament mechanical properties influence muscle function is not fully understood. Here we review information on the material properties of thick filaments, thin filaments, and their primary constituents; we also discuss ways in which mechanical properties of filaments impact muscle performance.

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Citations

Mar 5, 2016·Proceedings. Biological Sciences·Christian RodeReinhard Blickhan
Nov 26, 2013·Journal of Molecular Evolution·Felipe N Soto-AdamesJim O Vigoreaux
Sep 22, 2012·Biophysical Journal·Bertrand C W TannerMark S Miller
Apr 27, 2016·Biochimica Et Biophysica Acta·Chun ChanJulien Ochala
Dec 20, 2018·Frontiers in Physiology·Jun FanJulien Ochala
Apr 17, 2020·Frontiers in Physiology·William W Muir, Robert L Hamlin
Aug 15, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Chenling Dong, Bin Chen

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