Comparative biomembrane permeation of tacrine using Yucatan minipigs and domestic pigs as the animal model

Journal of Pharmaceutical Sciences
A V GoreY W Chien

Abstract

Tacrine (THA), a centrally acting acetylcholine-esterase inhibitor, is presently administered perorally for the treatment of Alzheimer's disease (AD). However, its low bioavailablity (i.e., 17%) and short half-life (2-4 h) demand the search for alternative routes of administration. The primary objective of this study was to assess the potential of absorptive mucosae and skin as routes for improving the systemic delivery of THA. The Yucatan minipig, which has been used increasingly in biomedical research as a useful model for humans, and the domestic pig, which is available at low cost, were evaluated for their suitability as animal model. Permeation kinetics of THA across various absorptive mucosae (nasal, buccal, sublingual, and rectal) of both species of swine were studied in the hydrodynamically well-calibrated Valia-Chien permeation cells. For comparison, permeation through various intestinal segments (duodenum, jejunum, and ileum) was also measured. Results indicated that both species display similar permeation characteristics. However, the data obtained for the domestic pigs shows lower intra- and inter-animal variabilities than that of the Yucatan minipigs. The nasal mucosa was found to have the highest permeability, whi...Continue Reading

References

Jan 1, 1992·Journal of Pharmaceutical Sciences·D Harris, J R Robinson
Jan 1, 1992·The American Journal of Clinical Nutrition·W F Caspary
Jun 1, 1991·Journal of Pharmaceutical Sciences·W G ReifenrathM S Kurtz
Mar 1, 1990·Journal of Pharmaceutical Sciences·D C CorboY W Chien
May 1, 1989·Pharmaceutical Research·P Tyle, P Agrawala
Jun 1, 1994·The Annals of Pharmacotherapy·M L Crismon
Jan 1, 1996·Journal of Geriatric Psychiatry and Neurology·D I KauferD Christine
Feb 1, 1997·Journal of Pharmaceutical Sciences·M K NairY W Chien

❮ Previous
Next ❯

Citations

Jan 15, 2005·Pharmaceutical Research·Rashmi S Upasani, Ajay K Banga
Jun 17, 2006·Pharmaceutical Research·Jeffery J PrusakiewiczRichard Voorman
May 17, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joseph A NicolazzoBarrie C Finnin
Jul 29, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M H QvistS Frokjaer
Dec 16, 2000·Pharmaceutical Science & Technology Today·A El-KattanS Haidar
Jan 6, 2009·BMC Neuroscience·Henry R CostantinoSteven C Quay
Apr 8, 2006·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Martin KunesJirí Bajgar
Feb 11, 2014·Drug Development and Industrial Pharmacy·Rachna KumriaBandar E Al-Dhubiab
Jan 11, 2014·Journal of Drug Targeting·Sumeet SoodK Gowthamarajan
Nov 26, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wei RenS Kevin Li
Apr 12, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Aranya ManosroiJiradej Manosroi
Aug 2, 2011·Theriogenology·S E Gillard KingmaT S Chenier
Mar 15, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Norihiro ShinkaiHitoshi Yamauchi
Jun 30, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·R P Dixit, S P Puthli
Nov 18, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ana M Barbero, H Frederick Frasch
Jul 24, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Viviana De CaroLibero Italo Giannola
Jan 26, 2007·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Ute JacobiJuergen Lademann
Aug 15, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Christopher H DaltonRobert P Chilcott
Jun 1, 2014·International Journal of Pharmaceutics·Mohammed SattarMajella E Lane
May 11, 2016·Cutaneous and Ocular Toxicology·Alain Stricker-KrongradGuy Bouchard
Nov 9, 2012·International Journal of Toxicology·Niels Christian GanderupWafa Harrouk
Dec 24, 2005·Pharmaceutical Development and Technology·George A PataniYie W Chien
Apr 18, 2014·PloS One·Annika Maria Juul HaagensenArne Astrup
Jun 15, 2021·Journal of Neurotrauma·Patricia Del CerroJorge E Collazos-Castro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Drug Development and Industrial Pharmacy
Marcílio S S Cunha-FilhoMariana Landin
Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
J M RawlingsM F Wilks
Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Takuji NakashimaTatsuya Oda
© 2022 Meta ULC. All rights reserved