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Comparative biotransformation of triflubazam in rats, dogs, and monkeys

Drug Metabolism and Disposition : the Biological Fate of Chemicals

Jan 1, 1975

K B AltonJennifer L McGuire

PMID: 1219

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Abstract

The biotransformation of 14C-triflubazam (ORF 8063; 1-methyl-5-phenyl-7-trifluoromethyl-1H-1,5-benzodiazepin-2-4-[3H,5H]-dione) was investigated in rats, dogs, and monkeys. Urinary metabolites, representing 65, 74, and 87%, respectively, of the total urinary radioactivity excreted by th...read more

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Platyrrhini
Canis familiaris
Monkeys
Methyl ether
Arene
trans-1,2-dihydro-1,2-naphthalenediol
Catechol
Portion of Urine
Smear Layer
Macaca fascicularis
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  • Comparative biotransformation of triflubazam in rats, dogs, and monkeys

    Drug Metabolism and Disposition : the Biological Fate of Chemicals

    Jan 1, 1975

    K B AltonJennifer L McGuire

    PMID: 1219

    DOI:

    Abstract

    The biotransformation of 14C-triflubazam (ORF 8063; 1-methyl-5-phenyl-7-trifluoromethyl-1H-1,5-benzodiazepin-2-4-[3H,5H]-dione) was investigated in rats, dogs, and monkeys. Urinary metabolites, representing 65, 74, and 87%, respectively, of the total urinary radioactivity excreted by th...read more

    Mentioned in this Paper

    Platyrrhini
    Canis familiaris
    Monkeys
    Methyl ether
    Arene

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