PMID: 1199945Dec 1, 1975Paper

Comparative cardiac dynamic effects of dobutamine and isoproterenol in conscious instrumented dogs

The American Journal of Cardiology
J E Hinds, E W Hawthorne

Abstract

The cardiac dynamic consequences were evaluated of constant infusions of dobutamine and isoproterenol at graded dose levels into conscious, healthy instrumented dogs. Measurements were made of simultaneous changes in left ventricular internal diameter, pressure, aortic pressure and rate of rise of left ventricular pressure(dP/dt), as well as the left ventricular electrogram. From these primary variables, derived variables were computed using programs in a minicomputer system. The data showed that, with increasing doses of dobutamine there were significant linear increases in all measured indexes of myocardial contractility, such as the rate of rise of left ventricular pressure at a developed isovolumic pressure of 40 mm Hg (dP/dt/P40), mean velocity of left ventricular fiber shortening, ejection fraction and stroke work. These changes in myocardial contractility occurred without changes in end-diastolic volume, mean aortic pressure or heart rate when dobutamine was infused in doses of 5 to 20 mug/kg per min. Isoproterenol also produced linear changes in indexes of myocardial contractility but in doses of 0.02 to 0.10 mug/kg per min, it produced a significantly higher heart rate at any given level of contractility than that prod...Continue Reading

References

May 1, 1974·Circulation Research·N W RobieJ L McNay
Oct 1, 1970·American Heart Journal·V S Bishop, L D Horwitz
Jul 1, 1967·Circulation Research·R R TaylorE H Sonnenblick
Dec 25, 1967·JAMA : the Journal of the American Medical Association·R M GunnarJ R Tobin
Nov 14, 1963·The New England Journal of Medicine·L I GOLDBERGA M ZIMMERMAN
Oct 1, 1964·The American Journal of Medicine·N KRASNOWR GORLIN

❮ Previous
Next ❯

Citations

Aug 1, 1977·Intensive Care Medicine·M RigaudJ P Bourdarias
Sep 1, 1979·Intensive Care Medicine·B RegnierB Teisseire
Nov 1, 1983·Medical & Biological Engineering & Computing·M C SinghR B Schuessler
Mar 1, 1981·Pharmacology, Biochemistry, and Behavior·A GrignoloP A Obrist
Jan 1, 1983·Pharmacology & Therapeutics·J P BourdariasJ Bardet
Sep 1, 1995·Progress in Cardiovascular Diseases·J E TisdaleB J Zarowitz
Jan 3, 1997·International Journal of Cardiology·M B MishraJ B Chambers
Jun 1, 1978·British Journal of Clinical Pharmacology·F WaagsteinA C Hjalmarson
Jul 25, 2007·Clinical and Experimental Pharmacology & Physiology·Helio C SalgadoRubens Fazan
Nov 1, 1996·Research in Veterinary Science·K McEnteeM Henroteaux
Aug 1, 1977·American Heart Journal·J J AndyP P Mehrotra
Jun 9, 1999·Anesthesiology·P Y GueugniaudB Riou
Nov 8, 2018·NMR in Biomedicine·Nikola CesarovicChristian T Stoeck
Jul 1, 1983·Medicinal Research Reviews·J A Bristol, D B Evans
Feb 17, 2021·Circulation. Cardiovascular Imaging·Kilian RunteLeonid Goubergrits
Dec 19, 2020·JACC. Clinical Electrophysiology·Carola GianniAndrea Natale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.