Comparative cellular biogerontology: primer and prospectus.

Ageing Research Reviews
Richard A MillerJames M Harper

Abstract

Most prior work on the biological basis of aging has focused on describing differences between young and old individuals but provided only limited insight into the mechanisms controlling the rate of aging. Natural selection has produced a goldmine of experimental material, in the form of species of differing aging rate, whose longevity can vary by 10-fold or more within mammalian orders, but these resources remain largely unexplored at the cellular level. In this review article we focus on one approach to comparative biogerontology: the strategy of evaluating the properties of cultured cells from organisms of varying lifespan and aging rate. In addition, we discuss problems associated with the analysis and interpretations of interspecific variation of cellular trait data among species with disparate longevity. Given the impressive array of 'natural experiments' in aging rate, overcoming the technical and conceptual obstacles confronting research in comparative cellular gerontology will be well worth the effort.

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Citations

May 13, 2011·The Journal of Experimental Biology·James M HarperRichard A Miller
Sep 8, 2015·Experimental Gerontology·Samantha J AlperJames M Harper
Jun 28, 2011·Mechanisms of Ageing and Development·Kurtis D SalwayJeffrey A Stuart
Jun 9, 2016·Experimental Gerontology·Karyn L Hamilton, Benjamin F Miller
Oct 31, 2018·GeroScience·Nicholas J SchorkUNKNOWN Workshop Speakers and Participants
Jul 27, 2017·Evolution; International Journal of Organic Evolution·Annette M KingDaryl P Shanley
Nov 10, 2020·Biological Reviews of the Cambridge Philosophical Society·Kang Nian YapWendy R Hood
Jun 17, 2021·GeroScience·Paul S Brookes, Ana Gabriela Jimenez
Jul 3, 2021·Biomedicines·James M Harper, Donna J Holmes
Jan 1, 2019·Functional Ecology·Csongor I VágásiPéter L Pap

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