PMID: 9539264Apr 16, 1998Paper

Comparative characterisation of the discriminative stimulus properties of clozapine and other antipsychotics in rats

Psychopharmacology
A J Goudie, A Taylor

Abstract

The discriminative stimulus properties of the prototypical atypical neuroleptic clozapine (5 mg/kg, IP) were characterised in rats using a fixed ratio assay. Clozapine induced full dose-related generalization in the absence of response suppression. Amphetamine and pentylenetetrazol failed to generalise at doses known to be discriminable, showing a degree of specificity for the clozapine cue. The typical neuroleptics haloperidol and loxapine induced minimal (20%) generalization at doses with marked behavioural effects; thus clozapine discrimination dissociates clozapine from typical neuroleptics. Atypical neuroleptics which are not clozapine congeners produced weak partial generalization when tested up to the highest doses that could be studied. The maximal levels of generalization induced by these agents were: amisulpiride 28%, risperidone 40% and sertindole 50%. Clozapine congeners typically caused more generalization, the novel pyridobenzoxapine JL13 inducing 70% maximal generalization. Most generalization (83%) was seen with the clozapine congener seroquel, although in contrast to clozapine, it only generalised at doses with marked effects on responding, so that no drug mimicked clozapine fully. Surprisingly, the clozapine c...Continue Reading

Citations

Jan 16, 2004·Pharmacology, Biochemistry, and Behavior·Andrew J GoudieJon C Cole
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Frank P BymasterDavid L Mckinzie
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·A J Goudie, J A Smith
Sep 3, 2002·Neuroscience and Biobehavioral Reviews·Marianna E JungMichael B Gatch
Jan 16, 2007·Behavioural Pharmacology·Andrew J GoudieHarry R Sumnall
Dec 5, 2002·Neurorehabilitation and Neural Repair·Larry B Goldstein, Sarah Bullman
Feb 18, 2017·International Journal of Molecular Sciences·Domenico de BerardisMassimo Di Giannantonio
Mar 3, 2007·Journal of Psychopharmacology·Andrew J GoudieHarry R Sumnall
Oct 17, 2008·Pharmacological Reviews·Jeffrey A LiebermanJohn G Csernansky
Feb 22, 2003·CNS Drug Reviews·Bart A Ellenbroek, Jean-François Liégeois

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