Comparative characterization of the canine normal prostate in intact and castrated animals

The Prostate
Chen-Li LaiErik Teske

Abstract

Prostate diseases in the dog are generally regarded as representative for their human counterparts. We characterized the normal canine prostate in comparison to the normal human prostate. Prostates of dogs were examined histomorphologically and by immunohistochemical detection of the markers CK14, HMWCK, CK5, CK18, CK7, UPIII, PSA, and PSMA. Histomorphologically, the canine prostate lacks the human zonal differentiation, has much more prominent acini, while comprising less stromal tissue. In general, the canine prostate epithelium displayed a highly differentiated character, with no cells expressing CK14, minimal amounts of cells expressing HMWCK/CK5 and the vast majority of cells expressing CK18 and PSA. After castration, the prostate epithelium regressed, and the remaining tubules were largely populated by cells showing a ductal phenotype (HMWCK+/CK5+/CK18+/CK7+). The human and canine prostate are histologically differently organized. The general scheme of cellular differentiation of the prostate epithelium may however be applicable to both species.

References

Dec 1, 1978·British Journal of Urology·R GhanadianE P O'Donoghue
Aug 1, 1988·The American Journal of Surgical Pathology·J E McNeal
Jan 1, 1989·The Prostate. Supplement·J T Isaacs, D S Coffey
Jan 1, 1989·Annals of the New York Academy of Sciences·D G De RooijA M Van Pelt
Mar 1, 1968·American Journal of Clinical Pathology·J E McNeal
Jan 1, 1981·The Prostate·J E McNeal
May 1, 1995·Journal of Veterinary Internal Medicine·F W BellW B Isaacs
Mar 1, 1997·British Journal of Urology·H W GottfriedR E Hautmann
May 20, 1999·Veterinary Pathology·A Espinosa de los MonterosJ Martín de las Mulas
Feb 26, 2000·Science·J M Slack
Jun 14, 2000·Animal Reproduction Science·S D JohnstonG R Johnston
Aug 19, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·G van LeendersJ Schalken
Apr 9, 2001·Veterinary Immunology and Immunopathology·W MahapokaiF J van Sluijs
Jan 5, 2002·Differentiation; Research in Biological Diversity·Y WangG Cunha
Nov 15, 2002·Molecular and Cellular Endocrinology·E TeskeJ A Schalken
Nov 28, 2002·Human Pathology·Paulette MhawechMarie-Françoise Pelte
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·W MahapokaiJ A Schalken
Jul 16, 2003·Journal of Comparative Pathology·V GriecoM Finazzi
Feb 24, 2006·The Prostate·Saurabh AggarwalSamuel R Denmeade

❮ Previous
Next ❯

Citations

Feb 12, 2014·Pakistan Journal of Biological Sciences : PJBS·M M P RodriguesR Laufer-Amorim
Apr 1, 2010·International Journal of Experimental Pathology·Silvana G P CamposSebastião R Taboga
Apr 26, 2013·Veterinary Clinical Pathology·Sarah L ColledgeKelley A Balog
Mar 23, 2015·Research in Veterinary Science·Carlos Eduardo Fonseca-AlvesRenée Laufer-Amorim
May 26, 2020·BMC Veterinary Research·N KuhntP Wefstaedt
Aug 27, 2019·American Journal of Veterinary Research·Florian WillmitzerHenning Richter
Oct 11, 2021·Veterinary Medicine and Science·Toby Ryman-TubbSimone de Brot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.