Comparative chronotropic activity of beta-adrenoceptive antagonists

British Journal of Pharmacology
A M Barrett, J Carter


1. Chronotropic dose-response curves (non-cumulative) for beta-adrenoceptive antagonists were constructed from results in rats anaesthetized with pentobarbitone and depleted of catecholamines by pre-treatment with syrosingopine.2. Depletion of catecholamines lowered resting heart rate and reduced the threshold to the chronotropic action of isoprenaline by about 50%. Eight beta-adrenoceptive antagonists produced a dose-dependent chronotropic response but the maximum response was in all cases smaller than that obtained with isoprenaline. The order of activity was dichloroisoprenaline>LB 46>practolol>INPEA>oxprenolol>pronethalol>alprenolol>I.C.I. 45,763 (Kö 592). Propranolol and sotalol were without significant activity. The duration of the chronotropic response to the antagonists was more prolonged than that to isoprenaline. Propranolol caused a parallel shift to the right of the dose-response curves for the agonist effects of the antagonists.3. Estimation of beta-adrenoceptor blocking activity in anaesthetized cats gave an order of activity dissimilar to that found for maximum agonist responses: LB 46 > oxprenolol > alprenolol > propranolol > I.C.I. 45,763 > practolol > dichloroisoprenaline > sotalol > INPEA > pronethalol.4. Con...Continue Reading


Jan 1, 1968·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·A M BarrettL H SMITH
Feb 10, 1967·Annals of the New York Academy of Sciences·J R Blinks
Jun 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·J V Levy, V Richards
Mar 1, 1970·European Journal of Pharmacology·J L Wale
Mar 1, 1969·Progress in Cardiovascular Diseases·B R Lucchesi, L S Whitsitt
Jan 1, 1966·British Journal of Pharmacology and Chemotherapy·T L Spriggs
Dec 1, 1963·British Journal of Pharmacology and Chemotherapy·L L IVERSEN
May 16, 1964·Lancet·J W BlackA C DORNHORST


May 1, 1972·The Journal of Clinical Pharmacology and New Drugs·D C HicksM Hills
Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·M BoucherP Duchêne-Marullaz
Jan 1, 1982·European Journal of Clinical Pharmacology·N TanakaH Tanaka
Apr 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Kaumann, J R Blinks
Mar 17, 1978·European Journal of Clinical Pharmacology·G CoccoF Follath
Jan 1, 1974·European Journal of Clinical Pharmacology·R GuglerH J Dengler
May 21, 1979·European Journal of Clinical Pharmacology·T L SvendsenJ Trap-Jensen
Jun 1, 1993·Cardiovascular Drugs and Therapy·J D Fitzgerald
Jun 1, 1973·European Journal of Pharmacology·B Delbarre, H Schmitt
Feb 1, 1973·European Journal of Pharmacology·R K SrivastavaK P Bhargava
Apr 1, 1975·European Journal of Pharmacology·J F GiudicelliJ R Boissier
Nov 1, 1975·European Journal of Pharmacology·B N SinghR M Whitlock
Feb 1, 1978·European Journal of Pharmacology·N HimoriT Ishimori
Feb 8, 1980·European Journal of Pharmacology·D DeitchmanR W Snyder
May 7, 1982·European Journal of Pharmacology·B Basil, R Jordan
Feb 12, 1985·European Journal of Pharmacology·M A Mian, E Malta
Dec 4, 1990·European Journal of Pharmacology·T TakashioS Onodera
Feb 18, 1992·European Journal of Pharmacology·M BoucherP Duchêne-Marullaz
Apr 21, 1983·The New England Journal of Medicine·W H Frishman
Feb 1, 1974·British Journal of Clinical Pharmacology·J M Ekue, R G Shanks
Jan 1, 1976·Acta Anaesthesiologica Scandinavica·J HolmboeE Normann
Sep 1, 1976·Clinical and Experimental Pharmacology & Physiology·F M WilliamsR Dorrington
Jan 1, 1986·Clinical and Experimental Pharmacology & Physiology·J F Marwood, G S Stokes
Jul 1, 1987·Clinical and Experimental Pharmacology & Physiology·J N PennefatherJ A Leedham
Sep 1, 1971·British Journal of Pharmacology·J D Fitzgerald, S R O'Donnell
Apr 1, 1972·British Journal of Pharmacology·C AdvenierJ F Giudicelli
Jun 1, 1973·British Journal of Pharmacology·B BasilD R Maxwell
Jul 1, 1977·British Journal of Pharmacology·R E BuckinghamD Robson
Apr 1, 1977·British Journal of Pharmacology·A G Blakeley, R J Summers
Nov 1, 1979·British Journal of Pharmacology·F J ImmsD A Powis
Feb 1, 1975·Thorax·E SowtonI Baker
Jan 12, 1974·British Medical Journal·G S StokesI R Thornell
Dec 1, 1974·The Journal of Clinical Investigation·M A WeberJ M Gain
Jan 1, 1974·Progress in Cardiovascular Diseases·D E Jewitt, B N Singh
Nov 1, 1976·The American Journal of Medicine·J V Levy
May 1, 1987·International Journal of Cardiology·R J Northcote
Nov 1, 1987·British Journal of Clinical Pharmacology·P M McCaffreyR G Shanks
Jan 1, 1982·British Journal of Clinical Pharmacology·B J ClarkA Bertholet
Jan 1, 1982·British Journal of Clinical Pharmacology·J F Giudicelli, F Lhoste
May 1, 1982·Clinical Cardiology·A J CammV B Whitmarsh
Jun 1, 1972·British Journal of Pharmacology·W G Nayler
Mar 1, 1973·Circulation·R E Goldstein
Jan 27, 1977·Nature·T P Kenakin, J W Black
Sep 1, 1986·British Journal of Pharmacology·M BoucherJ L Moundanga
Aug 1, 1973·The Journal of Pharmacy and Pharmacology·C Raper, E Malta
Jan 1, 1979·Clinical and Experimental Pharmacology & Physiology·R A FergusonJ L Wale
Sep 1, 1986·British Journal of Pharmacology·A J Kaumann, B M Lobnig
Dec 1, 1985·British Journal of Clinical Pharmacology·P C O'ConnorR G Shanks
Apr 25, 2019·Nature Biomedical Engineering·Luke A MacQueenKevin Kit Parker
Apr 1, 1983·British Journal of Clinical Pharmacology·M B FinchR G Shanks
Jan 1, 1982·British Journal of Clinical Pharmacology·A SvenssonL Hansson
Sep 3, 1977·The Medical Journal of Australia·P Bjerle

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