Comparative clinical study of roxithromycin and josamycin for suppurative skin and soft tissue infections by a double-blind method

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
N NoharaH Tagami

Abstract

The clinical efficacy and safety of Roxithromycin (RU 28965, RU), a new macrolide preparation, were compared with those of Josamycin (JM) in superficial suppurative skin infections. The study was designed as double-blind controlled trial with daily dosages of 300 mg in RU group and 1200 mg in JM group. A total of 209 cases (RU:105; JM:104) was analyzed and the final global improvement rating was 82.9% in the RU group and 80.8% in the JM group; there was no significant difference between the two groups. Slight adverse reactions were observed in 3.6% (4 cases) of the RU group and in 4.6% (5 cases) of the JM group. In conclusion, RU at daily doses of 300 mg is as effective as JM at daily doses of 1200 mg in superficial suppurative skin infections.

Citations

Jan 20, 2012·The Cochrane Database of Systematic Reviews·Sander KoningJohannes C van der Wouden

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