Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients

Clinical Therapeutics
Jinhyun KimYeong Wook Song

Abstract

S-adenosylmethionine (SAMe) has antiinflammatory and analgesic effects and has been reported to ameliorate the pain and dysfunction of osteoarthritis (OA). The metabolism of SAMe can be affected by geographic or ethnic factors. However, its efficacy and tolerability versus NSAIDs have not been reported in an Asian population. This study compared the efficacy and tolerability of SAMe 1200 mg/d and nabumetone 1000 mg/d in Korean patients with knee OA. This study was an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV clinical trial. Eligible patients were aged >18 years and had knee OA according to the clinical and radiologic criteria of the American College of Rheumatology, with a symptom duration of > or =3 months and with a baseline pain rating of >40 mm on a visual analog scale (VAS) or a pain rating on the VAS that was increased by >10 mm or 20% during the washout period compared with the screening visit. After a washout period of 2 weeks, patients with OA were randomly assigned to receive SAMe 1200 mg/d (400 mg TID) or nabumetone 1000 mg once a day in the evening for 8 weeks. The primary end point was the patient's assessment of pain intensity using a VAS at week 8, and the secondary end points were fun...Continue Reading

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Citations

Apr 27, 2011·International Journal of Rheumatic Diseases·Evan S Vista, Chak S Lau
Nov 29, 2013·International Journal of Molecular Sciences·Daniel J LeongHui B Sun
Jan 15, 2014·Neuroscience Letters·Benjamin V IneichenMichael Linnebank
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Aug 23, 2017·Expert Opinion on Therapeutic Targets·Heng LiJianping Zuo
Oct 9, 2020·Cell Proliferation·Yang OuyangShengrong Sun

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