Abstract
A randomized two-period crossover trial was carried out to compare the efficacy, tolerability and patient acceptability of two transdermal ('patch') formulations of glyceryl trinitrate. 'Deponit' 5 and 'Transiderm-Nitro' 5, both designed to deliver 5 mg glyceryl trinitrate in 24 hours. All patients were treated for 4 weeks with each of the formulations, changed once per day. Forty-seven patients entered the trial and all completed both phases of treatment. Both drugs resulted in highly significant mean reductions in angina attack frequency, the reduction being significantly greater with 'Deponit'. Similarly, mean sublingual glyceryl trinitrate consumption was also reduced; again, the greater reduction with 'Deponit' was significant. In terms of effectiveness, 'Deponit' was preferred to 'Transiderm-Nitro' by 19 patients, whilst only 5 patients preferred 'Transiderm-Nitro' (p less than 0.01). In terms of ease of application, comfort, appearance and adhesion (assessed in relation to daytime, night-time, washing, bathing and exercising), there were no appreciable or significant differences between patients' assessments of the two forms. Neither treatment had any appreciable effect on heart rate or blood pressure. Both formulations ...Continue Reading
References
Jul 1, 1986·British Journal of Clinical Pharmacology·D P NichollsP Morton
Aug 1, 1987·The American Journal of Cardiology·J C CowanD G Julian
Mar 25, 1988·The American Journal of Cardiology·H DogarC Demiroglu
Mar 25, 1988·The American Journal of Cardiology·R GrecoF Marsico
Mar 25, 1988·The American Journal of Cardiology·D E Rezaković, J Stalec
Jan 1, 1988·European Heart Journal·D E RezakovićM Majacić
Jun 1, 1985·British Heart Journal·M A JamesP R Wilkinson
Jan 1, 1985·European Heart Journal·K Dickstein, H Knutsen
Jan 1, 1985·The Journal of International Medical Research·A B TattersallM Carr
Jan 1, 1984·The Journal of International Medical Research·K M BridgmanA B Tattersall
Sep 1, 1984·European Heart Journal·M A NaafsA J Dunning
Sep 1, 1984·European Heart Journal·B CerriG Pollavini
Jan 1, 1985·Pharmaceutical Research·M WolffV Luckow
Citations
Jun 6, 2009·Advances in Therapy·Linda AbetzSimu Thomas
Nov 28, 2002·Clinical Pharmacokinetics·Yie W Chien, Senshang Lin
May 12, 2001·Tropical Medicine & International Health : TM & IH·M JawaraJ Rowley
Mar 4, 2014·PloS One·Jonathan CôtéMichèle Bouchard
Jul 1, 1997·The British Journal of Dermatology·M M Cameron