PMID: 6112861Jan 1, 1981Paper

Comparative cytogenetic study of a continuous human cell line and its subline susceptible and resistant, respectively, to coxsackie B3 virus

Acta Virologica
Y E KhesinA N Narovlyansky

Abstract

Cytogenetic characteristics of the J-96 human cell line and its J-41 subline, highly susceptible and resistant, respectively, to coxsackie B3 virus, were compared. The J-41 subline, as compared to the original J-96 line, had fewer chromosomes in the modal class cells (54-57 and 58-62, respectively) mostly at the expense of normal chromosomes. In most J-41 cells chromosome 21 was eliminated and the number of homologues of chromosomes 2, 9, 11, and 12 was reduced. The percentage of marker chromosomes in the J-41 subline (31.3) was slightly higher than in the J-96 line (24.3). The relationship between differences in the karyotypes and properties of the cultures such as resistance to coxsackie B3 virus, capacity to produce virus-induced interferon and to acquire an antiviral state after treatment with interferon were discussed.

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.