PMID: 7523530Oct 1, 1994Paper

Comparative cytokine release from human monocytes, monocyte-derived immature mast cells, and a human mast cell line (HMC-1)

The Journal of Investigative Dermatology
J GrabbeB M Czarnetzki

Abstract

To obtain further information regarding the role of cytokines during mast cell differentiation, we have investigated changes of cytokine secretion in mast cells developing from the human peripheral blood monocytic cell fraction during culture with fibroblast-derived conditioned media. The influence of stem cell factor and an antibody to the respective receptor in our culture system was studied as well. Interleukin (IL)-1 alpha, IL-1 beta, IL-6, and tumor necrosis factor (TNF)alpha were spontaneously secreted by cultured cells at day 1 and decreased markedly by day 14. Similar changes occurred also during culture with stem cell factor and were partially abrogated by an anti-receptor antibody. IL-8 was secreted at a high level throughout the culture, whereas no spontaneous secretion of IL-2, IL-3, IL-4, and IL-7 was measured at all. Upon stimulation with phorbol myristate acetate and A23187, cultured cells showed substantially more release of IL-3 and TNF-alpha after 14 d of culture, compared to peripheral blood monocytic cells. Preformed TNF-alpha was found in one of three monocytic cell preparations from peripheral blood, but not in monocytic cell-derived mast cells. During mast cell differentiation, cytokines from monocytic ce...Continue Reading

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Citations

Jan 1, 1994·Archives of Dermatological Research·J GrabbeB M Czarnetzki
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vladislav TemkinFrancesca Levi-Schaffer
Nov 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pia WelkerSebastian Bachmann
Aug 1, 2003·Immunopharmacology and Immunotoxicology·Hye-Young ShinHyung-Min Kim
Feb 28, 2001·Expert Opinion on Investigational Drugs·T C Theoharides, G R Sant
Oct 28, 1999·Experimental Dermatology·T ZuberbierB M Henz
May 22, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Bita ShakooryGuha Krishnaswamy
Jan 6, 2004·European Journal of Haematology·Michael AlexandrakisTheoharis C Theoharides
Nov 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·S PageC L Armour
May 8, 1999·The British Journal of Dermatology·L AckermannM Horsmanheimo
Jun 24, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J QiuW Jiranek
Jul 27, 2006·Fundamental & Clinical Pharmacology·Véronique Freund-Michel, Nelly Frossard
Feb 13, 2018·Immunological Reviews·Hanna BonnekohKaroline Krause
May 29, 1998·The British Journal of Dermatology·E ToppeB M Henz
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y OkayamaD D Metcalfe
Aug 1, 1995·Experimental Dermatology·B M CzarnetzkiT Zuberbier
Feb 14, 2019·Experimental & Molecular Medicine·So-Yoon WonEung-Gook Kim
Nov 21, 1997·Biochemical and Biophysical Research Communications·K YanoS J Galli
Nov 17, 2001·The Journal of Investigative Dermatology·J GailitB L Gruber

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