Abstract
Glycyrrhiza glabra L. (Fabaceae), commonly known as 'liquorice', is a well-known medicinal plant. Roots of this plant have long been used as a sweetening and flavouring agent in food and pharmaceutical products, and also as a traditional remedy for cough, upper and lower respiratory ailments, kidney stones, hepatitis C, skin disorder, cardiovascular diseases, diabetes, gastrointestinal ulcers and stomach ache. Previous pharmacological and clinical studies have revealed its antitussive, antiinflammatory, antiviral, antimicrobial, antioxidant, immunomodulatory, hepatoprotective and cardioprotective properties. While glycyrrhizin, a sweet-tasting triterpene saponin, is the principal bioactive compound, several bioactive flavonoids and isoflavonoids are also present in the roots of this plant. In the present study, the cytotoxicity of the methanol extracts of nine samples of the roots of G. glabra, collected from various geographical origins, was assessed against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cell lines using the in vitro 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide cell toxicity/viability assay. Considerable variations in levels of cytotoxicity were obse...Continue Reading
References
Jan 1, 1991·Chemical & Pharmaceutical Bulletin·K HirabayashiN Yamamoto
Apr 1, 1991·Planta medica·H AkamatsuY Niwa
Dec 16, 1983·Journal of Immunological Methods·T Mosmann
May 1, 2008·Phytotherapy Research : PTR·Marjan Nassiri Asl, Hossein Hosseinzadeh
Aug 16, 2008·Journal of Chromatography. a·Qingying Zhang, Min Ye
Apr 14, 2009·European Journal of Pharmacology·Panneerselvam KalaiarasiKodukkur Viswanathan Pugalendi
Aug 29, 2009·Journal of Agricultural and Food Chemistry·Yi-Te YoAi-Li Shiau
Jul 7, 2011·Journal of Cellular Physiology·Gunjan SharmaPijush K Das
Nov 21, 2012·Oncology Reports·Marianne SchmidtRudolf Hagen
Jan 18, 2013·Cytotechnology·Ebubekir Dirican, Hasan Turkez
Jan 28, 2014·Bioorganic & Medicinal Chemistry Letters·Junho SongSung-Hoon Kim
Mar 4, 2014·Phytochemical Analysis : PCA·Norazah BasarSatyajit D Sarker
Mar 20, 2014·British Journal of Pharmacology·Ming-Ju HsiehHui-Ling Chiou
May 16, 2014·Bulletin of Experimental Biology and Medicine·O V Astaf'eva, L T Sukhenko
Jun 26, 2014·BioMed Research International·Jian-yuan LiMing-yu Sun
Jul 1, 2014·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R ZhouH Chen
Jul 21, 2014·Food Chemistry·Mariateresa RussoSanto Postorino
Aug 6, 2014·Toxicology and Applied Pharmacology·Hao ZhengJing Yang
Citations
Feb 18, 2016·Phytotherapy Research : PTR·Shao-Ru ChenYi-Tao Wang
Jul 2, 2016·Phytotherapy Research : PTR·Kashif M KhanSatyajit D Sarker
Sep 21, 2016·BMC Complementary and Alternative Medicine·Siat Yee FongTien Huynh
Feb 1, 2017·Journal of Natural Products·Kai LiMin Ye
Jun 2, 2017·Phytotherapy Research : PTR·Tasmia TahsinSatyajit Dey Sarker
Mar 16, 2018·Nutrition and Cancer·Behjat Javadi
Oct 23, 2018·Phytotherapy Research : PTR·Peter A SegunSatyajit D Sarker
Nov 30, 2019·Natural Product Research·Soh DésiréNyassé Barthélemy
Nov 29, 2016·Asian Pacific Journal of Tropical Medicine·Jie ChenXin-Li Gu
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yves Salomon MakongSatyajit Dey Sarker
Aug 6, 2021·Oxidative Medicine and Cellular Longevity·Javad Sharifi-RadHafiz Ansar Rasul Suleria