Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells

Phytotherapy Research : PTR
Norazah BasarSatyajit D Sarker

Abstract

Glycyrrhiza glabra L. (Fabaceae), commonly known as 'liquorice', is a well-known medicinal plant. Roots of this plant have long been used as a sweetening and flavouring agent in food and pharmaceutical products, and also as a traditional remedy for cough, upper and lower respiratory ailments, kidney stones, hepatitis C, skin disorder, cardiovascular diseases, diabetes, gastrointestinal ulcers and stomach ache. Previous pharmacological and clinical studies have revealed its antitussive, antiinflammatory, antiviral, antimicrobial, antioxidant, immunomodulatory, hepatoprotective and cardioprotective properties. While glycyrrhizin, a sweet-tasting triterpene saponin, is the principal bioactive compound, several bioactive flavonoids and isoflavonoids are also present in the roots of this plant. In the present study, the cytotoxicity of the methanol extracts of nine samples of the roots of G. glabra, collected from various geographical origins, was assessed against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cell lines using the in vitro 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide cell toxicity/viability assay. Considerable variations in levels of cytotoxicity were obse...Continue Reading

References

May 1, 2008·Phytotherapy Research : PTR·Marjan Nassiri Asl, Hossein Hosseinzadeh
Aug 16, 2008·Journal of Chromatography. a·Qingying Zhang, Min Ye
Apr 14, 2009·European Journal of Pharmacology·Panneerselvam KalaiarasiKodukkur Viswanathan Pugalendi
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Citations

Feb 1, 2017·Journal of Natural Products·Kai LiMin Ye
Jun 2, 2017·Phytotherapy Research : PTR·Tasmia TahsinSatyajit Dey Sarker
Nov 30, 2019·Natural Product Research·Soh DésiréNyassé Barthélemy
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yves Salomon MakongSatyajit Dey Sarker
Aug 6, 2021·Oxidative Medicine and Cellular Longevity·Javad Sharifi-RadHafiz Ansar Rasul Suleria

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