Comparative diagnostic accuracy of magnetic resonance imaging and immunoscintigraphy for detection of bone marrow involvement in patients with malignant lymphoma

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
C AltehoeferM Langer

Abstract

To compare the diagnostic accuracy of magnetic resonance imaging (MRI) and immunoscintigraphy (IS) for detection of bone marrow infiltration in malignant lymphoma. In 32 patients with Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL), MRI of the axial skeleton and whole-body IS using technetium-99m (99mTc)-labeled monoclonal antibodies were reviewed and compared with iliac crest biopsies. Criterion for marrow infiltration was a positive biopsy or concordant positive results of MRI and IS. In 16 patients (50%), MRI, IS, and iliac crest biopsies were negative for marrow infiltration. Iliac crest biopsy showed infiltration in only four patients (13%). Infiltration was missed in two of 32 patients with IS and in one patient with MRI. In one additional patient, MRI was false-positive because of pelvic hematopoietic hyperplasia. A subset of nine patients (28%) with negative biopsies had bone marrow involvement according to MRI and IS with identical location and pattern of infiltration. In eight of these nine patients, diagnostic imaging indicated marrow involvement only in noncrest marrow. Subsequent biopsy confirmed infiltration in five patients. The clinical course suggested true-positive imaging results in the remaining four ...Continue Reading

Citations

Apr 2, 1999·Medical and Pediatric Oncology·A VaranM Büyükpamukçu
May 26, 1999·The Journal of Pathology·D Jones, C D Fletcher
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonG P Canellos
Mar 29, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Sheila C Rankin
Apr 24, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Sarah J Vinnicombe, Rodney H Reznek
Oct 24, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Sandip BasuAbass Alavi
Apr 4, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Nadir Alexander GhanemMathias Langer
Jul 19, 2002·Nuclear Medicine Communications·Drazen HuićD L Munz
Feb 27, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Michal Weiler-SagieOra Israel
Mar 8, 2008·British Journal of Haematology·Thomas C KweeRutger A J Nievelstein
Jun 12, 2021·The British Journal of Radiology·N Ari WijetungaJoachim Yahalom
Dec 21, 2007·European Journal of Radiology·K L Verstraete, W C J Huysse

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.