Jul 1, 1976

Comparative doses and costs of antipsychotic medication

Archives of General Psychiatry
J M Davis

Abstract

It is clinically useful to have a table listing the equivalent doses of the various neuroleptics to a standard, such as chlorpromazine. This article derives such data by reviewing double-blind controlled studies that used a flexible dosage schedule of neuroleptics in treating schizophrenic patients. Each neuroleptic is then converted to 100-mg chlorpromazine equivalents. This empirically derived dosage comparability table is compared with a similar table derived from the opinions of experts. Since these comparable doses produce equivalent amounts of antipsychotic activity, the cost to provide such medication was then calculated, and a table comparing the costs of the different neuroleptics was constructed. In absolute amounts, the cost differences between drugs are small. However, for any drug, large savings accrue when the largest possible capsule or tablet to achieve the desired dose is prescribed.

  • References
  • Citations216

References

  • We're still populating references for this paper, please check back later.

Mentioned in this Paper

Antipsychotic Effect
Schizophrenia
Microbial Anatomical Capsule Structure
Antipsychotic Agents
Chlorpromazine
Clinical Trials
Structure of Organ Capsule
Therapeutic Equivalency

About this Paper

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here