Comparative ecologic relationships of saturated fat, sucrose, food groups, and a Mediterranean food pattern score to 50-year coronary heart disease mortality rates among 16 cohorts of the Seven Countries Study

European Journal of Clinical Nutrition
D KromhoutDavid R Jacobs

Abstract

We studied the ecologic relationships of food groups, macronutrients, eating patterns, and an a priori food pattern score (Mediterranean Adequacy Index: MAI) with long-term CHD mortality rates in the Seven Countries Study. Sixteen cohorts (12,763 men aged 40-59 years) were enrolled in the 1960s in seven countries (US, Finland, The Netherlands, Italy, Greece, former Yugoslavia: Croatia/Serbia, Japan). Dietary surveys were carried out at baseline and only in a subsample of each cohort. The average food consumption of each cohort was chemically analyzed for individual fatty acids and carbohydrates. Ecologic correlations of diet were computed across cohorts for 50-year CHD mortality rates; 97% of men had died in cohorts with 50-year follow-up. CHD death rates ranged 6.7-fold among cohorts. At baseline, hard fat was greatest in northern Europe, olive oil in Greece, meat in the US, sweet products in northern Europe and the US, and fish in Japan. The MAI was high in Mediterranean and Japanese cohorts. The 50-year CHD mortality rates of the cohorts were closely positively ecologically correlated (r = 0.68-0.92) with average consumption of hard fat, sweet products, animal foods, saturated fat, and sucrose, but not with naturally occurri...Continue Reading

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Citations

Oct 12, 2018·Scientific Reports·Alessandro Menotti, Paolo Emilio Puddu
Sep 27, 2018·International Journal of Molecular Sciences·Ganapathy SivakumarLuigi Gentile
Jun 20, 2018·European Journal of Clinical Nutrition·W Philip T James
Jan 27, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jean-Pierre Montani
Jan 8, 2021·Nutrition Research Reviews·Jacques Delarue
Feb 10, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Gian Luigi RussoPasquale Strazzullo
May 17, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Paolo E Puddu, Alessandro Menotti
Jun 15, 2021·The British Journal of Nutrition·Jacques Delarue

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