PMID: 6108555Jul 1, 1980Paper

Comparative effect of cimetidine and ranitidine on prolactin secretion

Postgraduate Medical Journal
G F Nelis, J G Van de Meene

Abstract

Cimetidine has been shown to stimulate prolactin secretion after a intravenous administration. Cimetidine 200 mg and ranitidine 50 mg was given i.v. in a randomly allocated order to 22 volunteers on consecutive days; these doses can be regarded as equivalent as far as inhibition of gastric acid output is concerned. Plasma prolactin was estimated at regular intervals. The prolactin stimulating effect of cimetidine was confirmed while ranitidine did not influence plasma prolactin levels. Although cimetidine and ranitidine seem to be equally effective in reducing gastric acid output, the effect of the drugs are not the same on their entire spectrum of action since ranitidine does not influence plasma prolactin. It still has to be established in clinical trials which drug is the best choice in clinical medicine.

References

Aug 1, 1977·The Journal of Clinical Endocrinology and Metabolism·H E Carlson, A F Ippoliti
Jan 1, 1979·British Journal of Clinical Pharmacology·W L BurlandG V Groom

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Citations

Feb 1, 1982·Digestive Diseases and Sciences·H G DammannB Simon
Jan 15, 1983·Experientia·E TarditiG Bertaccini
Jan 1, 1985·Pharmacology & Therapeutics·M C GerberJ R Bianchine
Jan 7, 1982·The New England Journal of Medicine·M DanilewitzB Hirschowitz
Dec 13, 1990·The New England Journal of Medicine·M Feldman, M E Burton
Feb 1, 1983·Postgraduate Medical Journal·F I LeeF T Costello
Mar 1, 1983·Journal of Clinical and Hospital Pharmacy·J DawsonR Cockel
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·S LalH Guyda
Jan 1, 1990·European Journal of Clinical Pharmacology·E C MeyerJ C Avenant
May 1, 1986·Medical Toxicology·J Penston, K G Wormsley
Dec 1, 1983·Drug Intelligence & Clinical Pharmacy·T S Gaginella, J H Bauman
Sep 1, 1981·The Journal of Pharmacy and Pharmacology·A H Robins, M L McFadyen
Jan 1, 1988·Annals of the New York Academy of Sciences·L BertaG Gaidano

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