Comparative Effect of Curcumin and Nanocurcumin on Nephroprotection at Cisplatin-induced Rats

Journal of Pharmacy & Bioallied Sciences
Ni Made D SandhiutamiTjoeng Mandy

Abstract

Cisplatin is a first-line chemotherapeutic agent for various solid tumors including ovarian and breast cancer. Thereby, it has been proven effective as an antineoplastic agent, but its clinically use is limited because of its nephrotoxicity side effect. This study aimed to investigate curcumin as a renoprotector agent against cisplatin nephrotoxicity. The samples used were curcumin and its nanoparticles formulated using ionic gelation method. The nephrotoxicity was investigated through several parameters such as serum creatinine, blood urea nitrogen, serum albumin, kidney weight ratio, and histopathology. These parameters were tested on rats and divided into the following four groups: normal group, negative control group that administered cisplatin with doses amount of 7 mg/kg body weight (BW) intraperitoneally, nanocurcumin group (cisplatin + nanocurcumin) and curcumin group (cisplatin + curcumin). The agents were administered at a dose of 100 mg/kg BW every day in 9 days before cisplatin administration. The sample of blood serum and kidneys organ were taken 48h after cisplatin administration. The negative control group showed a significant increase in serum creatinine, blood urea nitrogen, and kidney weight ratio, whereas it ...Continue Reading

References

Feb 15, 2008·Kidney International·N Pabla, Z Dong
Dec 19, 2012·Journal of Bioscience and Bioengineering·Masaaki UekiNobuhiro Maekawa
Mar 5, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Yenny PrasajaRetnosari Andrajati
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