Comparative effect of repeated ingestion of difructose anhydride III and palatinose on the induction of gastrointestinal symptoms in humans

Bioscience, Biotechnology, and Biochemistry
Akiko TamuraHiroshi Hara

Abstract

We evaluated the safety and change in fermentability from repeated ingestion of difructose anhydride III (DFAIII) in humans. A randomized controlled single-blind crossover study with thirteen subjects was conducted. Each subject ingested 5 g of DFAIII or palatinose daily for 12 days, before and after which the subject was loaded with 10 g of DFAIII and had breath hydrogen measured from 0 to 9 h (DL test) to evaluate the fermentability of DFAIII. The defecation frequency and abdominal symptom score were the same between each ingestion period. Moreover, DFAIII ingestion had no influence on blood test results. Only the breath hydrogen excretion in post-DFAIII ingestion was slightly higher at h 8 than the pre-ingestion. Consequently, repeated ingestion of DFAIII for 12 days was as safe as palatinose ingestion, especially with respect to abdominal symptoms and blood test results, and its high resistance to enterobacterial fermentation in humans was not impaired.

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Citations

Jun 24, 2006·Bioscience, Biotechnology, and Biochemistry·Akiko TamuraKiyoshi Ebihara
Mar 8, 2007·Bioscience, Biotechnology, and Biochemistry·Kyoko TomitaHiroshi Hara
Jul 24, 2010·Journal of Nutritional Science and Vitaminology·Masayo NakamoriShigeru Yamamoto
Oct 14, 2006·Archives of Animal Nutrition·Akiko TamuraNaomichi Nishimura
Aug 30, 2011·Applied Microbiology and Biotechnology·Hua HangMing Miao
Feb 25, 2018·Applied Microbiology and Biotechnology·Yingying ZhuWanmeng Mu
Jun 17, 2006·Chemical Communications : Chem Comm·Patricia BalbuenaJosé M García Fernández
Mar 30, 2021·Critical Reviews in Food Science and Nutrition·Mei ChengWanmeng Mu

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