To compare the effectiveness of different types of splenectomy in children with congenital hemolytic anemias. We constructed key questions that addressed outcomes relevant to clinicians and families on effects of partial or total splenectomy, including hematologic effect, splenic function, and the risk of adverse events. We identified from Pubmed and Embase 703 studies that evaluated different types of splenectomy and accepted 93 studies that satisfied entry criteria. We graded the quality of each report and summarized the overall strength of research evidence for each key question. We did not identify any randomized clinical trials. All types of splenectomy have favorable clinical outcomes in most diseases. We did not identify any hematologic advantage of laparoscopy compared with laparotomy. Adverse events are uncommon in most studies and are minimized with use of laparoscopy. There is a need for randomized clinical trials and improved data collection of different types of splenectomy in congenital hemolytic anemias. Outcomes studied should address the concerns of families and clinicians to assess the risks and benefits of various treatments.
Serum immunoglobulins, IgG subclasses, isohemagglutinins and complement-3 levels in patients with thalassemia major
Long-term evaluation of the beneficial effect of subtotal splenectomy for management of hereditary spherocytosis.
Clinical and hematologic benefits of partial splenectomy for congenital hemolytic anemias in children
Occurrence of overwhelming gram-negative infections in splenectomised patients with thalassaemia major
Congenital dyserythropoietic anemia type II: epidemiology, clinical appearance, and prognosis based on long-term observation.
Risk factors for acute chest syndrome in children with sickle cell disease undergoing abdominal surgery
Acute chest syndrome shows a predilection for basal lung regions on the side of upper abdominal surgery
Fibrocongestive splenomegaly in sickle cell disease: a distinct clinicopathological entity in the Eastern province of Saudi Arabia
Congenital dyserythropoietic anemia type I (CDA I): molecular genetics, clinical appearance, and prognosis based on long-term observation.
Near-total splenectomy for hereditary spherocytosis: clinical prospects in relation to disease severity
Portal vein thrombosis after splenectomy in pediatric hematologic disease: risk factors, clinical features, and outcome
Laparoscopic versus open abdominal surgery in children with sickle cell disease is associated with a shorter hospital stay
Splenectomy in hereditary spherocytosis: Review of 1,657 patients and application of the pediatric quality indicators
Clinico-hematological profile of hereditary spherocytosis: experience from a tertiary care center in North India
AHRQ series paper 5: grading the strength of a body of evidence when comparing medical interventions--agency for healthcare research and quality and the effective health-care program
American College of Surgeons National Surgical Quality Improvement Program Pediatric: a phase 1 report
Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia
Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry
Spleen hydatidosis treated by hemi-splenectomy: A low-morbidity, cost-effective management by a recently improved surgical technique
Splenectomy to Optimize Hemoglobin S Control in Children With Sickle Cell Anemia on Chronic Transfusion Therapy for Stroke Prevention
Total versus partial splenectomy in pediatric hereditary spherocytosis: A systematic review and meta-analysis
Clinical and laboratory outcomes following total or partial splenectomy in patients with hereditary spherocytosis
Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.