Comparative effectiveness of faecal microbiota transplant by route of administration

The Journal of Hospital Infection
N D GundackerJ M Rodriguez

Abstract

The optimal route of delivery for faecal microbiota transplant (FMT) is unknown. This observational single-centre study analysed the two-week cure rates for all patients who received FMT from 2013 to 2016 according to route of delivery. Overall, nasogastric delivery of FMT was less effective than lower endoscopic delivery. When patients were stratified by illness severity, nasogastric delivery achieved similar cure rates in healthier individuals, whereas lower endoscopic delivery was preferred for relatively ill individuals. Nasogastric delivery may be less effective than lower endoscopic delivery; however, when taking the cost, preparation and potential risk into account, this difference may not be clinically significant for patients with mild disease.

Citations

Jun 26, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Sonia Bouri, Ailsa Hart
Sep 11, 2020·Experimental & Molecular Medicine·John Chulhoon Park, Sin-Hyeog Im
Mar 25, 2020·Critical Care : the Official Journal of the Critical Care Forum·Matteo BassettiAndrea Gori
Nov 5, 2019·Advances in Colloid and Interface Science·Adi SeifertYoav D Livney
Jun 4, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Monica GulatiLipika Chandwani

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