Comparative effectiveness of H7N9 vaccines in healthy individuals

Human Vaccines & Immunotherapeutics
Dan ZhengZe Chen

Abstract

Avian H7N9 influenza viruses possess a potential pandemic threat to public health worldwide, and have caused severe infection and high mortality in humans. A series of clinical trials of H7N9 vaccines have been completed. Meta-analyses need to be performed to assess the immunogenicity and safety of H7N9 vaccines. Database research with defined selection criteria was conducted in PubMed, Cochrane Central Register of Controlled Trials, the World Health Organization's International Clinical Trials Registry Platform, ClinicalTrials.gov, etc. Data from randomized clinical trials regarding the immunogenicity and safety of H7N9 vaccines were collected and meta-analyzed. For non-adjuvanted H7N9 vaccines, high dose formulations induced limited immunogenicity and increased the risk of local and systemic adverse events, simultaneously. For adjuvanted H7N9 vaccines, on the one hand, ISCOMATRIX, MF59, AS03 and aluminium adjuvants applied in H7N9 vaccines could improve immune responses effectively, and non-aluminium adjuvants had superior performance in saving vaccine dose; on the other hand, aluminium adjuvant had the advantages of safety amongst these adjuvants applied in H7N9 vaccines. H7N9 influenza vaccines with adjuvant might represent...Continue Reading

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Citations

Jan 8, 2021·Biotechnology Journal·Jingdi Pan, Zongqiang Cui
Feb 8, 2021·Biochemical and Biophysical Research Communications·Eduardo Alfredo AdamiPaulo Lee Ho
Feb 24, 2021·Immunopharmacology and Immunotoxicology·Zhaoxue HuHuibin Zhang
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Clinical Trials Mentioned

NCT01995695
NCT02274545
NCT01897701
NCT01928472
NCT01938742
NCT01942265
NCT01999842
NCT02436928
NCT02480101
NCT02206464

Software Mentioned

Excel
Stata

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