Comparative effectiveness of mechanically and electrically powered negative pressure wound therapy devices: a multicenter randomized controlled trial

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
David G ArmstrongRobert S Kirsner

Abstract

This study was designed to compare the ultraportable mechanically powered Smart Negative Pressure (SNaP) Wound Care System (Spiracur, Sunnyvale, CA) with the electrically powered Vacuum-Assisted Closure (VAC) Therapy System (Kinetic Concepts, Inc. [KCI], San Antonio, TX) in a multicenter, comparative efficacy, noninferiority-powered, randomized controlled trial. We enrolled 132 people with noninfected, nonischemic, nonplantar lower extremity diabetic and venous wounds. Each subject was randomly assigned (1:1) to treatment with either system in conjunction with appropriate off-loading and compression therapy. The trial evaluated treatment for up to 16 weeks or complete wound closure (defined as complete reepithelialization without drainage). Primary end point analysis of wound size reduction found that SNaP-treated subjects demonstrated noninferiority to the VAC-treated subjects at 4, 8, 12, and 16 weeks (p = 0.0030, 0.0130, 0.0051, and 0.0044, respectively). Kaplan-Meier analysis showed no significant difference in complete wound closure between SNaP- and VAC-treated subjects at all time points. Device related adverse events and complications such as infection were also similar between treatment groups. These data support simil...Continue Reading

References

Feb 28, 2002·Journal of the American Academy of Dermatology·David J MargolisMona Baumgarten
Jan 13, 2005·JAMA : the Journal of the American Medical Association·Nalini SinghBenjamin A Lipsky
Nov 18, 2005·Lancet·David G ArmstrongUNKNOWN Diabetic Foot Study Consortium
Jun 27, 2006·Plastic and Reconstructive Surgery·Louis C ArgentaLisa R David
Jun 8, 2007·Journal of Wound Care·M LeijnenJ Oskam
May 23, 2008·International Wound Journal·Penny E CampbellJennifer M Smith
Sep 3, 2008·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Mustafa KeskinNedim Savaci
Mar 27, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Malin MalmsjöElizabeth Huddleston
Jun 16, 2009·The British Journal of Dermatology·C J MoffattA Steptoe
Nov 12, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Chandan K SenMichael T Longaker
Oct 5, 2010·Plastic and Reconstructive Surgery·Bruce LermanPeter J Schubart
Mar 3, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·David G ArmstrongRobert S Kirsner

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Citations

Oct 11, 2015·Diabetes/metabolism Research and Reviews·Caitlin S Garwood, John S Steinberg
Sep 3, 2013·The Medical Clinics of North America·Adam L Isaac, David G Armstrong
Jun 8, 2013·Dermatologic Therapy·Nanjin J ParkVickie R Driver
Feb 22, 2013·International Wound Journal·Robert G FrykbergEdward Tierney
Dec 21, 2013·Journal of the American Academy of Dermatology·Afsaneh AlaviRobert S Kirsner
Apr 8, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Susan M RheeKaren A Robinson
Sep 5, 2015·Advances in Wound Care·Robert G Frykberg, Jaminelli Banks
Dec 7, 2013·The Lancet Infectious Diseases·Daniel P O'BrienPhilipp du Cros
Aug 25, 2016·Plastic and Reconstructive Surgery·Ersilia L Anghel, Paul J Kim
Jul 15, 2015·The Cochrane Database of Systematic Reviews·Jo C DumvilleFrank Peinemann
Oct 18, 2018·The Cochrane Database of Systematic Reviews·Zhenmi LiuFrank Peinemann
Feb 16, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Lisa Gould, William W Li
May 16, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Robert KirsnerHenry Jaimes
Oct 10, 2019·The Journal of Bone and Joint Surgery. American Volume·Hansel Gould B CocjinJose Maria R Coruña
Oct 8, 2014·Plastic and Reconstructive Surgery. Global Open·Adam L IsaacDavid G Armstrong
Nov 26, 2019·The Journal of Bone and Joint Surgery. American Volume·Hansel Gould B CocjinJose Maria R Coruña
Mar 23, 2019·International Wound Journal·Ian J Y WeeTjun Y Tang
Oct 31, 2017·Journal of the American Medical Directors Association·Barbara J Messinger-RapportJulie K Gammack

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