PMID: 3762351Sep 1, 1986Paper

Comparative effectiveness of metronidazole, hyperglycemia and hyperthermia in irradiation of Ehrlich carcinoma with fast neutrons

Meditsinskaia radiologiia
V N LetovM Iu Pavlov

Abstract

A study was made of a possibility of the modification of the effects of fast neutrons (with the mean energy of about 6 MeV.) by local hyperthermia (HT), short-term induced hyperglycemia (STIH) and metronidazole (MZ). The study was conducted in vivo on intramuscularly transplantable ascitic mouse Ehrlich's carcinoma. The dose-effect relationship built up in different time after the day of irradiation, was considered in parallel with the time course of tumor growth; regression curves were obtained using computer. Using the value of 50% tumor growth inhibition and the ratio of areas under the model dose-effect curves as criteria of a degree of modification the authors have come to a conclusion that HT possesses the most noticeable intensifying effect.

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