PMID: 321488Apr 1, 1977Paper

Comparative effectiveness of nine hypnotic drugs: sleep laboratory studies

Journal of Clinical Pharmacology
A KalesM B Scharf

Abstract

The effectiveness of nine hypnotic drugs was compared using a standard protocol in separate sleep laboratory drug evaluation studies. All of these drugs were relatively effective in improving sleep with initial and short-term use. However, with intermediate-term use (two weeks), most of the drugs showed a marked decrease in their effectiveness. Following withdrawal, sleep was similar to baseline with most of the drugs, continued to be improved with flurazepam (Dalmane), 30 mg, and worsened beyond baseline levels with triazolam (U33030), 0.5 mg. The determination of a drug's effectiveness with continued use is most important clinically in enabling the physician to rationally and effectively use hypnotic drugs in the adjunctive treatment of insomnia.

References

Nov 1, 1976·Clinical Pharmacology and Therapeutics·A KalesP Silberfarb
Sep 1, 1975·Clinical Pharmacology and Therapeutics·A KalesM B Scharf
Oct 16, 1975·The New England Journal of Medicine·A Kales, J D Kales
Sep 1, 1970·Archives of General Psychiatry·A KalesJ D Kales

❮ Previous
Next ❯

Citations

Jul 1, 1979·Journal of Clinical Pharmacology·A KalesE O Bixler
Jul 28, 1976·Psychopharmacology·P M Adams, E S Barratt
Jan 1, 1982·European Journal of Clinical Pharmacology·J M MontiL D'Angelo
Mar 1, 1984·Electroencephalography and Clinical Neurophysiology·G D Novack, K M Owenburg
Jul 16, 1982·European Journal of Pharmacology·H C Rosenberg, T H Chiu
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·H C Rosenberg, T H Chiu
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·R R GriffithsJ V Brady
May 28, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Richard C Oude VoshaarFrans G Zitman
Nov 28, 1981·Lancet·J D Parkes
Aug 11, 1983·The New England Journal of Medicine·D J GreenblattD R Abernethy
Jun 1, 1982·Acta Psychiatrica Scandinavica·C R Soldatos, A Kales
Jan 1, 1982·Journal of Clinical Pharmacology·M LinnoilaA Brendle
Jul 1, 1987·Journal of Clinical Pharmacology·A KalesR L Manfredi
Mar 1, 1985·Journal of Clinical Pharmacology·E O BixlerC R Soldatos
Sep 1, 1989·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·E Merlo Pich, R Samanin
Jun 29, 1999·Otolaryngologic Clinics of North America·W H Obermeyer, R M Benca
Nov 1, 1996·Neurologic Clinics·W H Obermeyer, R M Benca
Sep 25, 2003·Sleep Medicine Reviews·Shawn D Youngstedt
Jan 13, 2006·Mental Retardation·Scott M DoranRobert H Horner
Sep 1, 1990·Hospital Practice·A Kales
Nov 1, 1990·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·E Teboul, G Chouinard
Jul 1, 1990·Scandinavian Journal of Primary Health Care·M Holm
Sep 17, 1987·The New England Journal of Medicine·D J GreenblattR I Shader
Mar 1, 1980·Postgraduate Medicine·J D KalesC R Soldatos
May 1, 1983·Pharmacotherapy·T RothF J Zorick
Jul 1, 1983·Drug Intelligence & Clinical Pharmacy·P D Kroboth, R P Juhl
Sep 15, 1978·Science·A KalesJ D Kales

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.