Comparative Effectiveness of Noninvasive and Invasive Ventilation in Critically Ill Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Critical Care Medicine
Mihaela S StefanPeter K Lindenauer

Abstract

To compare the characteristics and hospital outcomes of patients with an acute exacerbation of chronic obstructive pulmonary disease treated in the ICU with initial noninvasive ventilation or invasive mechanical ventilation. Retrospective, multicenter cohort study of prospectively collected data. We used propensity matching to compare the outcomes of patients treated with noninvasive ventilation to those treated with invasive mechanical ventilation. We also assessed predictors for noninvasive ventilation failure. Thirty-eight hospitals participating in the Acute Physiology and Chronic Health Evaluation database from 2008 through 2012. A total of 3,520 patients with a diagnosis of chronic obstructive pulmonary disease exacerbation including 27.7% who received noninvasive ventilation and 45.5% who received invasive mechanical ventilation. None. Noninvasive ventilation failure was recorded in 13.7% from patients ventilated noninvasively. Hospital mortality was 7.4% for patients treated with noninvasive ventilation; 16.1% for those treated with invasive mechanical ventilation; and 22.5% for those who failed noninvasive ventilation. In the propensity-matched analysis, patients initially treated with noninvasive ventilation had a 41%...Continue Reading

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Citations

Oct 21, 2016·Intensive Care Medicine·Lorenzo Del SorboV Marco Ranieri
May 17, 2019·Clinical Medicine : Journal of the Royal College of Physicians of London·Dipansu Ghosh, Mark W Elliott
Jun 17, 2015·Critical Care Medicine·Davide ColomboGianmaria Cammarota
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Nov 7, 2018·BMJ Open Respiratory Research·Nicholas David LaneStephen C Bourke
Oct 16, 2015·Critical Care Medicine·Mihaela S StefanPeter K Lindenauer
May 26, 2017·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Bruno do Valle Pinheiro
May 15, 2020·Intensive Care Medicine Experimental·Ingeborg HospachMarkus Storr
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May 26, 2017·Annals of the American Thoracic Society·Anuj B MehtaAllan J Walkey
Jan 10, 2016·Therapeutic Advances in Respiratory Disease·Marieke L DuivermanPeter J Wijkstra
Jul 11, 2018·Journal of Intensive Care·Hadrien WiniszewskiGilles Capellier
Aug 3, 2021·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Min DingJun Duan

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