Comparative effectiveness of primary tumor resection in patients with stage III pancreatic adenocarcinoma

BMC Cancer
Ke SunHong Wu

Abstract

Previous studies comparing primary tumor resection (PTR) to palliative treatment for advanced-stage pancreatic ductal adenocarcinoma (PDA) were limited by strong selection bias. We used multiple methods to control for confounding and selection bias to estimate the effect of PTR on survival for late-stage PDA. Surveillance, Epidemiology, and End Results (SEER) 18 registry database for 2004 through 2014 was retrieved for the present study. A total of 4322 patients with stage III (AJCC, 6th) PDA were included in this study. Propensity score matching (PSM) was performed to eliminate possible bias. In addition, instrumental variable (IV) analysis was utilized to adjust for both measured and unmeasured confounders. A total of 4322 patients with stage III PDA including 552 (12.8%) who underwent PTR, 3770 (87.2%) without PTR, were identified. In the multivariable cohort, a clear prognostic advantage of PTR was observed in overall survival (OS) (P < 0.001) and disease-specific survival (DSS) (P < 0.001) compared to patients after non-surgery therapy. In the PSM cohort, patients in PTR group showed a better OS and DSS (both P values < 0.001) compared to patients in non-surgery group. The survival benefit of PTR for stage III PDA was not ...Continue Reading

References

Jul 26, 2006·Annals of Surgical Oncology·Gauri R VaradhacharyRobert A Wolff
Jan 15, 2008·Journal of Health Economics·Joseph V TerzaPaul J Rathouz
Sep 25, 2008·Cancer Control : Journal of the Moffitt Cancer Center·Gregory M Springett, Sarah E Hoffe
Apr 20, 2010·Journal of the National Cancer Institute·John L GoreUNKNOWN Urologic Diseases in America Project
Sep 9, 2010·JAMA : the Journal of the American Medical Association·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Oct 12, 2010·Cardiovascular and Interventional Radiology·Timm DeneckeMatthias Glanemann
Aug 26, 2011·The New England Journal of Medicine·Vanja VaccaroMichele Milella
Apr 19, 2012·JAMA : the Journal of the American Medical Association·Hung-Jui TanDavid C Miller
Mar 7, 2014·Statistics in Medicine·Michael BaiocchiDylan S Small
Aug 26, 2014·World Journal of Gastroenterology : WJG·Nicole E LopezAndrew M Lowy
Jun 13, 2015·Annals of Surgical Oncology·Eran SadotPeter J Allen
Jul 24, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Joal D BeaneHenry A Pitt
Sep 24, 2015·JAMA : the Journal of the American Medical Association·Thomas S ValleyColin R Cooke
Jun 12, 2016·Journal of Vascular and Interventional Radiology : JVIR·Ugo ScemamaJérôme Soussan
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Aug 9, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Margaret A TemperoSusan Darlow
May 15, 2018·Journal of Gastrointestinal Oncology·Andreas Minh LuuChris Braumann
Jun 30, 2018·Cancer Treatment Reviews·Luis SabaterAndrés Cervantes

❮ Previous
Next ❯

Methods Mentioned

BETA
patients with surgical

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.