Comparative effectiveness of second-generation antidepressants for accompanying anxiety, insomnia, and pain in depressed patients: a systematic review

Depression and Anxiety
Kylie J ThalerGerald Gartlehner

Abstract

Patients with major depressive disorder (MDD) often suffer from accompanying symptoms that influence the choice of pharmacotherapy with second-generation antidepressants (SGAs). We conducted a systematic review to determine the comparative effectiveness of citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, desvenlafaxine, duloxetine, venlafaxine, bupropion, mirtazapine, nefazodone, and trazodone, for accompanying anxiety, insomnia, and pain in patients with MDD. We conducted searches in multiple databases including MEDLINE®, Embase, the Cochrane Library, International Pharmaceutical Abstracts, and PsycINFO, from 1980 through August 2011 and reviewed reference lists of pertinent articles. We dually reviewed abstracts, full-text articles, and abstracted data. We included randomized, head-to-head trials of SGAs of at least 6 weeks' duration. We grouped SGAs into three classes for the analysis: selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors, and others. We graded the strength of the evidence as high, moderate, low, or very low based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group (GRADE) approach. We located 19 head...Continue Reading

References

Apr 1, 1994·Journal of Clinical Psychopharmacology·L A CunninghamE Hearst
Jul 14, 1999·Journal of Affective Disorders·G ChouinardM C O'Neill
Oct 21, 1999·International Clinical Psychopharmacology·M F FlamentZ Ying
Feb 11, 2000·The Annals of Pharmacotherapy·G D Garrison, G M Levin
Apr 18, 2001·American Journal of Preventive Medicine·R P HarrisUNKNOWN Methods Work Group, Third US Preventive Services Task Force
May 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A J RushA Metz
May 10, 2002·The Journal of Clinical Psychiatry·Michael J DetkeMark A Demitrack
Jul 24, 2002·The International Journal of Neuropsychopharmacology·Andre De NayerAnnick Mignon
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
Jan 8, 2004·Psychosomatics·David J GoldsteinMark A Demitrack
Jul 2, 2004·The American Journal of Psychiatry·Mark ZimmermanSteve Singer
Jul 3, 2004·Journal of Clinical Psychopharmacology·David J GoldsteinMark A Demitrack
Oct 27, 2004·Journal of Psychiatric Research·Stephen K BrannanAlan F Schatzberg
Dec 14, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Michael J DetkeIstvan Bitter
Feb 9, 2005·CNS Drugs·Marcio VersianiUNKNOWN Comparative Efficacy Antidepressants Study Group
May 16, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·D G S PerahiaM J Detke
Mar 29, 2007·Annals of Family Medicine·Bradley N GaynesMaurizio Fava
Jan 15, 2009·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Richard A HansenBradley N Gaynes
May 26, 2009·Lancet·Erick TurnerAlex J Sutton
May 26, 2009·Lancet·Michaela-Elena Seyringer, Siegfried Kasper
May 26, 2009·Lancet·Gerald GartlehnerKathleen N Lohr
Apr 21, 2010·Health Information and Libraries Journal·Andrea L ChapmanGerald Gartlehner
Jul 16, 2010·Pharmacoepidemiology and Drug Safety·Hyungjin Myra KimMarcia Valenstein
Jan 7, 2011·Journal of Clinical Epidemiology·Howard BalshemGordon H Guyatt

❮ Previous
Next ❯

Citations

Aug 15, 2013·Psychotherapy and Psychosomatics·Emilie OliéSylvaine Artero
Jul 20, 2014·Clinics in Geriatric Medicine·Benoit H MulsantMark J Rapoport
Feb 20, 2016·Pain Practice : the Official Journal of World Institute of Pain·Eiad A Ramzy
Mar 5, 2013·Respiratory Physiology & Neurobiology·Matthew R HodgesGary C Mouradian
Oct 5, 2013·Journal of Neuroscience Methods·John L ShannonhouseCaurnel Morgan
Mar 3, 2015·Journal of Psychiatric Research·Yi-Ju PanKuei-Hong Kuo
Dec 17, 2014·Journal of Affective Disorders·Sharon C SungUNKNOWN COMED Study Team
Jan 21, 2014·Journal of Psychosomatic Research·Randy A SansoneMichael W Wiederman
Apr 30, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Hee-Ju KangJae-Min Kim
Aug 4, 2016·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Sidney H KennedyUNKNOWN CANMAT Depression Work Group
Nov 23, 2017·Frontiers in Molecular Neuroscience·Keren OvedNoam Shomron
Sep 9, 2015·International Journal of Psychiatry in Medicine·Murielle GirardDominique Malauzat
Apr 22, 2014·The Korean Journal of Pain·Somayyeh NaderiUlker Cankurt
Apr 16, 2015·Journal of Clinical Psychopharmacology·Siegfried AlbertiAlessandro Serretti
May 16, 2018·The Cochrane Database of Systematic Reviews·Hazel EverittSue Wilson
Apr 30, 2021·Frontiers in Psychiatry·William H RoughanMiguel E Rentería

❮ Previous
Next ❯

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