Comparative effectiveness research using matching-adjusted indirect comparison: an application to treatment with guanfacine extended release or atomoxetine in children with attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder

Pharmacoepidemiology and Drug Safety
James E SignorovitchEric Q Wu

Abstract

To illustrate a matching-adjusted indirect comparison by comparing the efficacy of guanfacine extended release (GXR) and atomoxetine (ATX) in reducing oppositional symptoms in children with attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder. Individual patient data were used from a GXR trial; only published summary data were used from ATX trials. In a matching-adjusted indirect comparison, individual patients from the GXR trial were weighted such that their mean baseline characteristics matched those published for ATX trials. Placebo-arm outcomes were then compared to further assess balance between the matched populations. Changes in the Conners' Parent Rating Scale-Revised Short Form Oppositional Subscale from baseline to endpoint among GXR-treated and ATX-treated patients were then compared. Before matching, the GXR (n = 143) and ATX (n = 98) trial populations had significant differences in baseline characteristics and placebo-arm outcomes. After matching, baseline characteristics were well balanced across trials, and placebo-arm outcomes became nearly identical. Comparing active treatment arms across the matched populations, GXR was associated with a significantly greater reduction in mean Co...Continue Reading

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Citations

Sep 4, 2015·Biometrical Journal. Biometrische Zeitschrift·Friedhelm Leverkus, Christy Chuang-Stein
Jul 15, 2015·Journal of Comparative Effectiveness Research·James E SignorovitchAnupama Kalsekar
Dec 1, 2013·Research Synthesis Methods·Sarah DoneganCatrin Tudur Smith
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May 11, 2012·Pharmacoepidemiology and Drug Safety·Sebastian SchneeweissScott R Smith
Jan 18, 2020·Journal of Comparative Effectiveness Research·Elyse SwallowJames Signorovitch
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May 29, 2021·Statistics in Medicine·Konstantina ChalkouGeorgia Salanti
Jul 2, 2021·Research Synthesis Methods·Antonio Remiro-AzócarGianluca Baio

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