PMID: 7522526Sep 1, 1994Paper

Comparative effects of a highly specific protein kinase C inhibitor, calphostin C and calmodulin inhibitors on angiotensin-stimulated aldosterone secretion

The Journal of Steroid Biochemistry and Molecular Biology
A Ganguly, C Waldron

Abstract

We have examined the relative roles of the calcium-calmodulin system and protein kinase C in angiotensin-mediated aldosterone secretion. We used a highly specific protein kinase C inhibitor, calphostin C and two well-accepted calmodulin inhibitors, W-7 and calmidazolium. Although both types of inhibitors affected angiotensin-induced aldosterone secretion, as judged by the inhibitory doses of these compounds, angiotensin-evoked aldosterone secretion was more sensitive to calmodulin inhibition than protein kinase C inhibition. Manipulation of OFFracellular calcium by dantrolene and thapsigargin also modified aldosterone secretion significantly.

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Citations

Jul 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·V BodartA De Léan
Jul 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·V PezziW E Rainey

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