Comparative effects of acute and chronic administration of caffeine on local cerebral glucose utilization in the conscious rat

European Journal of Pharmacology
A NehligP Vert

Abstract

The quantitative 2-[14C]deoxyglucose autoradiographic method was used to compare the effects of acute and chronic administration of caffeine on rat brain energy metabolism. The acute intravenous administration of caffeine (10 mg/kg) to naive rats induced widespread increases in glucose utilization in 20 of 62 structures, mainly in striatal and related areas as well as in the 2 raphe nuclei and the locus coeruleus. After 2 weeks' chronic intraperitoneal injection of caffeine (10 mg/kg), increases in glucose utilization were seen in 6 of 62 structures: the substantia nigra, pars compacta, dorsal raphe, locus coeruleus and the 3 parts of the caudate nucleus. An acute caffeine injection (10 mg/kg) to these chronically caffeine-treated rats induced a further increase in glucose utilization in 9 additional structures but there was no significant difference in the effects of an acute administration of caffeine whether the rats had been chronically pretreated with caffeine or saline. The results of the present study show that brain energy metabolism seems to be subject to only partial tolerance to central stimulation by caffeine.

References

Jan 1, 1978·Neuropharmacology·E B Arushanian, Y B Belozertsev
Mar 1, 1986·Brain Research·E Garcia-Rill
Apr 1, 1973·The Journal of Pharmacy and Pharmacology·U Strömberg, B Waldeck
Jan 3, 1969·Science·M Jouvet
Feb 1, 1972·The Journal of Pharmacy and Pharmacology·H CorrodiG Jonsson
Feb 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·A ThithapandhaJ R Gillette
May 18, 1984·European Journal of Pharmacology·A NehligL Sokoloff
Nov 5, 1982·European Journal of Pharmacology·S J Grant, D E Redmond
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S H SnyderJ W Daly
Jul 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·T V DunwiddieB B Fredholm
Jun 1, 1982·Acta Physiologica Scandinavica·B B Fredholm
Mar 7, 1983·Life Sciences·J P BoulengerP J Marangos
Mar 1, 1984·Psychiatry Research·D R CherekJ T Brauchi
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L Sokoloff
Nov 1, 1949·Electroencephalography and Clinical Neurophysiology·G Moruzzi, H W Magoun

❮ Previous
Next ❯

Citations

Sep 25, 2009·Psychopharmacology·Merideth A Addicott, Paul J Laurienti
Aug 22, 1989·European Journal of Pharmacology·H SchroederA Nehlig
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·G Tanda, S R Goldberg
Mar 12, 1999·Neuroscience and Biobehavioral Reviews·A Nehlig
Jan 12, 2008·Journal of Psychopharmacology·Oliver West, Gareth Roderique-Davies
Jun 20, 2017·Journal of Psychopharmacology·Lilani J ArulkadachamMathew Ling
Feb 9, 2018·Neurochemical Research·Simonetta CamandolaMark P Mattson
Mar 16, 2005·Behavioural Pharmacology·O Cauli, M Morelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.