PMID: 9444521Jan 1, 1997Paper

Comparative effects of adenosine-5'-triphosphate and related analogues on insulin secretion from the rat pancreas

Fundamental & Clinical Pharmacology
J ChapalM M Loubatieres-Mariani

Abstract

Adenosine tri- and diphosphate (ATP and ADP) and their structural analogues stimulate insulin secretion from the isolated perfused rat pancreas, an effect mediated by P2Y-purinoceptor activation. Concerning the base moiety of the nucleotide, it was previously shown that purine but not pyrimidine nucleoside triphosphates were active and that substitution on purine C2 with the 2-methylthio group greatly enhanced the potency. In this study, we further analyze the consequences of ribose and polyphosphate chain modifications. Modifications in 2' and 3' position on the ribose led to a decrease in insulin response when bulky substitutions were made: indeed, 2'-deoxy ATP was similar in activity to ATP, whereas arylazido-aminopropionyl ATP (ANAPP3) was weakly effective and trinitrophenyl ATP (TNP-ATP) was inactive. Substitution on the gamma phosphorus of the triphosphate chain led to a decrease (gamma-anilide ATP) or no change (gamma-azido ATP) in potency; the replacement of the bridging oxygen between beta and gamma phosphorus by a peroxide group did not significantly change the activity, whereas substitution by a methylene group completely abolished stimulation of insulin secretion. As for the phosphorothioate analogues, adenosine-5'-...Continue Reading

References

Jan 1, 1975·Journal of Supramolecular Structure·S J Jeng, R J Guillory
Nov 16, 1979·European Journal of Pharmacology·M M Loubatieres-MarianiG Valette
Jul 1, 1992·British Journal of Pharmacology·D Hillaire-BuysM M Loubatières-Mariani
Jul 1, 1990·Physiological Reviews·R A Olsson, J D Pearson
Feb 1, 1985·British Journal of Pharmacology·G BurnstockL A Meldrum
Jan 1, 1985·General Pharmacology·G Burnstock, C Kennedy
Jan 15, 1986·The Biochemical Journal·J L Gordon
Oct 1, 1988·British Journal of Pharmacology·V Ralevic, G Burnstock
Apr 7, 1987·European Journal of Pharmacology·D Hillaire-BuysM M Loubatières-Mariani
Aug 1, 1987·British Journal of Pharmacology·G BertrandM Roye
Nov 12, 1986·European Journal of Pharmacology·S M HouraniN J Cusack
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Jul 30, 1982·European Journal of Pharmacology·D G Satchell, M H Maguire
Aug 1, 1983·British Journal of Pharmacology·G BurnstockP Meghji
May 1, 1981·British Journal of Pharmacology·J Chapal, M M Loubatieres-Mariani
Jun 4, 1982·European Journal of Pharmacology·P Lukacsko, R D Krell
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·T K HardenR A Nicholas
Jun 6, 1995·Biochemical and Biophysical Research Communications·Y TokuyamaG I Bell

❮ Previous
Next ❯

Citations

Mar 28, 2008·Purinergic Signalling·I Novak
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Feb 24, 2010·Journal of Medicinal Chemistry·Shay EliahuBilha Fischer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.