Comparative effects of avocado oil and losartan on blood pressure, renal vascular function, and mitochondrial oxidative stress in hypertensive rats

Nutrition
Cristian Adrián Márquez-RamírezChristian Cortés-Rojo

Abstract

Angiotensin II (Ang-II) antagonism alleviates hypertensive kidney damage by improving mitochondrial function and decreasing oxidative stress. This condition also is associated with altered renal vascular tone due to enhanced constriction by Ang-II. Thus, approaches ameliorating these events are desirable to alleviate kidney damage. Avocado oil, a source of antioxidants and oleic acid, is known to improve mitochondrial function, while oleic acid has antihypertensive effects. Therefore, the aim of this study was to test whether avocado oil counteracts, to a similar degree as the Ang-II blocker losartan, the deleterious effects of hypertension on blood pressure, renal vascular performance, kidney mitochondrial function, and oxidative stress. Hypertensive rats induced with Nω-nitro-l-arginine methyl ester (L-NAME) were supplemented during 45 d with avocado oil or losartan. Vascular responses were analyzed in perfused kidney. Membrane potential, reactive oxygen species levels, and glutathione were analyzed in isolated kidney mitochondria. In hypertensive rats, avocado oil decreased 21.2% and 15.5% diastolic and systolic blood pressures, respectively, and alleviated impaired renal vasodilation. Hypertension decreased membrane potenti...Continue Reading

Citations

Mar 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mei WangIkhlas A Khan
Jun 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcos FloresJaime Ortiz-Viedma
Dec 10, 2020·Food Research International·Norma Julieta Salazar-LópezG A González-Aguilar
Jun 20, 2021·Comprehensive Reviews in Food Science and Food Safety·Braulio Cervantes-Paz, Elhadi M Yahia

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