Comparative effects of catechin, epicatechin and N-Ω-nitroarginine on quinolinic acid-induced oxidative stress in rat striatum slices

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Daniel Santamaría-Del ÁngelHugo Juárez-Olguín

Abstract

The aim of this work was to compare the effects of catechin (CAT), epicatechin (EPI) and N-ω-l-nitroarginine (L-NARG) on different endpoints of oxidative stress induced by quinolinic acid (QUIN) in a simple tissue preparation, rat striatal slices - with particular emphasis in the glutathione system - in order to provide revealing information on the antioxidant efficacy of these agents in an excitotoxic model. Rat striatal slices were incubated for 1h in the presence of 100 μM QUIN and/or 85 μM CAT or EPI, or 100 μM L-NARG. Lipid peroxidation (LP) and the levels of reduced and oxidized glutathione (GSH and GSSG) were determined. The three agents tested completely blocked the QUIN-induced lipid peroxidation and recovered the QUIN-induced altered GSH/GSSG balance. No statistical differences were detected among the protective effects exerted by these antioxidants, suggesting similar efficacy and common antioxidant mechanisms. The antioxidant properties exhibited by these molecules on the excitotoxic model tested herein support an active role of glutathione and prompt their use as therapeutic tools in models of neurodegenerative disorders.

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Citations

Jun 28, 2017·Redox Report : Communications in Free Radical Research·K Parasram
Sep 22, 2017·Critical Reviews in Food Science and Nutrition·Lingxi Li, Baoshan Sun
Feb 23, 2018·Current Drug Discovery Technologies·Tahereh FarkhondehSaeed Samarghandian
Feb 25, 2020·Critical Reviews in Food Science and Nutrition·Zhihao QuSheng Zhang
May 15, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Neeraja Revi, Aravind Kumar Rengan

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