Comparative effects of cyclosporin on glycosaminoglycan synthesis by gingival fibroblasts

Journal of Periodontology
J Newell, C R Irwin

Abstract

Histological studies show that drug-induced gingival overgrowth results from an accumulation of the connective tissue component. Despite comprising a major part of gingival connective tissue, a role for glycosaminoglycans (GAGs) in the pathogenesis of gingival overgrowth has received scant attention. By analyzing the metabolism of 3H-glucosamine, we have compared GAG and hyaluronan synthesis by fibroblasts derived from normal and overgrown gingival tissue, and the effects of cyclosporin on GAG output. GAG production was cell density-dependent, fibroblasts cultured at low density synthesizing significantly increased quantities in comparison to confluent cultures. The effects of cyclosporin on GAG synthesis was also found to be both cell density- and cell strain-dependent. However, cyclosporin-stimulated GAG synthesis by 2/3 overgrown cell strains and 1/3 normal strains. These results suggest that a direct promotion of GAG synthesis by gingival fibroblasts in response to cyclosporin may play a role in the pathogenesis of gingival overgrowth.

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Citations

Jun 9, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nicoletta GaglianoMagda Gioia
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Thomas FehrPatrice M Ambühl
Jul 1, 2008·Transplantation Proceedings·S A P CondéM G Bastos
Jun 18, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G StabelliniE M Calvi
Mar 26, 2004·Archives of Oral Biology·Helen J WrightJohn B Matthews
Feb 21, 2004·Journal of Periodontology·Nelson GnoattoMônica V Marquezini
May 8, 2001·Journal of Periodontology·R S Morton, A I Dongari-Bagtzoglou
Jun 8, 2001·Journal of Periodontology·J MirandaC Mendieta
Aug 10, 2001·Journal of Periodontology·M I UzelP C Trackman
Dec 29, 2000·Journal of Periodontology·L BreschiF Bernardi
May 16, 2003·Journal of Periodontology·Paula L HylandChris R Irwin
Jun 10, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·P C Trackman, A Kantarci
Oct 9, 2001·European Journal of Clinical Investigation·L BrunetC Mendieta
Oct 25, 2007·Journal of Periodontal Research·N GnoattoM V Marquezini
May 19, 2004·Clinical and Experimental Immunology·C JohnssonG Tufveson

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