PMID: 1347223Jan 1, 1992Paper

Comparative effects of desflurane and isoflurane on vecuronium-induced neuromuscular blockade

Journal of Clinical Anesthesia
A F Ghouri, P F White


To evaluate the neuromuscular effects of a nondepolarizing muscle relaxant (vecuronium) during anesthesia with equipotent concentrations of either desflurane or isoflurane. Randomized open study comparing effects of desflurane and isoflurane on vecuronium-induced neuromuscular blockade. University-affiliated medical center. Forty-five healthy adults undergoing elective surgical procedures randomly assigned to receive either desflurane, nitrous oxide (N2O), and vecuronium or isoflurane, N2O, and vecuronium for maintenance of general anesthesia. Following a standardized induction sequence, patients receiving either desflurane and N2O or isoflurane and N2O were administered bolus doses of vecuronium equal to 0.01, 0.02, or 0.03 mg/kg intravenously (IV) during the maintenance period. Neuromuscular transmission was measured using a Relaxograph monitor. Vecuronium produced similar depression of neuromuscular function at equipotent (50% of the minimum alveolar concentration) end-tidal concentrations of isoflurane 0.6% and desflurane 3.0%. Following administration of vecuronium 0.01 to 0.03 mg/kg IV, onset times (3.4 +/- 0.4 minutes to 3.2 +/- 0.4 minutes and 3.2 +/- 0.5 minutes to 3.0 +/- 0.6 minutes), maximum T1 twitch depression (80...Continue Reading


Jul 11, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T M HemmerlingH Schwilden
Jun 1, 1996·Journal of Clinical Anesthesia·T J GanP S Glass
May 1, 1997·Journal of Clinical Anesthesia·K E GriffithS A Garg
Aug 6, 1999·Journal of Clinical Anesthesia·G K LighthallJ G Brock-Utne
Oct 1, 1996·Anesthesia and Analgesia·D W KimE R Johnson

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