Abstract
Although amrinone has favorable hemodynamic effects in patients with congestive heart failure, little is known about its effects on coronary blood flow (CBF). We compared the effects of intravenous low-dose dobutamine and amrinone on CBF in 10 patients with dilated cardiomyopathy using a Doppler guidewire. We infused dobutamine at a dose of 5 and 10 microg/kg/min for 5 min. After the end of each stage, coronary flow velocity (CFV) and coronary arterial diameter (CAD) in the proximal left anterior descending coronary artery, and hemodynamic variables were obtained. After the CFV and hemodynamics returned to baseline, we infused 1 mg/kg of amrinone over 5 min, and obtained these variables at 5 and 10 min after the cessation of the infusion. CAD did not increase with dobutamine, but significantly increased after amrinone (% increase: 10 +/- 7%; P < 0.001 vs. baseline). CFV progressively increased with dobutamine (5 microg/kg/min: 21 +/- 26%; P < 0.05 vs. baseline; 10 microg/kg/min: 53 +/- 42%; P < 0.005 vs. baseline and 5 microg/kg/min), but slightly decreased after amrinone (-4 +/- 17%; P = not significant vs. baseline). CBF increased during dobutamine (5 microg/kg/min: 25 +/- 29%; P < 0.05; 10 microg/kg/min: 66 +/- 55%; P < 0.00...Continue Reading
References
Nov 1, 1979·Circulation Research·A A AlousiC J Opalka
Jul 1, 1976·The American Journal of Cardiology·S L MeyerJ T Willerson
Aug 15, 1992·The American Journal of Cardiology·E J EichhornP A Grayburn
May 1, 1992·Circulation·J W DoucetteJ Segal
Nov 1, 1990·The American Journal of Cardiology·R H MarcusP Sareli
Apr 1, 1990·American Heart Journal·P SundramK T Weber
Sep 1, 1989·Circulation·D A CoxA P Selwyn
Sep 1, 1989·Circulation·H DrexlerT Bonzel
Sep 1, 1988·Progress in Cardiovascular Diseases·C W WhiteM L Marcus
Mar 1, 1986·The American Journal of Physiology·G RubanyiR J Paul
Aug 1, 1986·Circulation·J GageT H LeJemtel
Jul 22, 1985·The American Journal of Cardiology·J R BenottiJ S Alpert
Sep 1, 1981·The American Journal of Cardiology·R BenderskyT A Ports
Nov 1, 1994·European Heart Journal·D R HoldrightP Collins
Feb 1, 1995·Journal of the American College of Cardiology·K NagataM Yokota
Mar 15, 1995·Circulation·I AntonyA Nitenberg
May 1, 1993·American Heart Journal·J L Dubois-RandéH Geschwind
Citations
Mar 4, 2009·Journal of Cardiac Failure·Kanu Chatterjee
Jun 26, 1998·Journal of Clinical Laser Medicine & Surgery
Jun 1, 1997·Catheterization and Cardiovascular Diagnosis·A E Iskandrian