PMID: 6983202Oct 1, 1982Paper

Comparative effects of etidocaine and lidocaine on nerve and neuromuscular conduction in the frog

Acta Anaesthesiologica Scandinavica
E L PostM D Sokoll

Abstract

The effects of etidocaine and lidocaine were studied on frog nerve and neuromuscular junction. Etidocaine is 10 times more potent than lidocaine in blocking nerve conduction. At pH 6.9, the first peak of the compound action potential is blocked more profoundly than is the second. At pH 7.2 and 7.5, both peaks are blocked to about the same degree. There was a dose-related decrease in miniature endplate potential (mepp) amplitude and acetylcholine sensitivity of the endplate region produced by both drugs. Lidocaine increased the time required for mepp repolarization, while with etidocaine receptor desensitization was observed.

References

Oct 1, 1976·Anesthesiology·G Strichartz
Apr 1, 1978·The Journal of Physiology·E Neher, J H Steinbach
Jan 1, 1975·Acta Anaesthesiologica Scandinavica. Supplementum·B Löfström
Mar 1, 1975·Anesthesia and Analgesia·D C MooreD F Lysons
Jul 11, 1957·The Journal of Physiology·B KATZ, S THESLEFF
Apr 28, 1955·The Journal of Physiology·J DEL CASTILLO, B KATZ

❮ Previous
Next ❯

Citations

Jan 13, 2015·International Scholarly Research Notices·M Saleet Jafri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.