Comparative effects of haloacetic acids in whole embryo culture

Teratology
E S HunterA M Richard

Abstract

A major class of disinfection by-products in drinking water are the haloacetic acids. Both dichloro- and trichloroacetic acids are teratogenic when administered to rats throughout organogenesis. However, there is little information regarding the developmental toxicity of other haloacetic acids. Therefore, 3-6 somite staged CD-1 mouse embryos were exposed to acetic acid (AA) or mono- (M), di- (D), and tri- (T) substituted fluoro- (F), chloro- (C), or bromo- (B) acetic acids in whole embryo culture in order to evaluate the effects of these agents on development. A 24 hour exposure to the haloacetic acids produced dysmorphogenesis. Effects on neural tube development ranged from prosencephalic hypoplasia to non-closure defects throughout the cranial region. Exposure to the haloacetic acids affected optic development, produced malpositioned and/or hypoplastic pharyngeal arches, and resulted in perturbation of heart development. In order to determine the relative toxicities of these agents, benchmark concentrations were calculated as the lower 95% confidence interval of the concentration that produced a 5% increase in neural tube defects. The benchmark concentrations occurred over a wide range with DFA (5912.6 microM) and MBA (2.7 mi...Continue Reading

References

Jul 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·G P TothM K Smith
Sep 1, 1992·Teratology·M K SmithJ A Stober
Sep 1, 1992·Teratology·D L EpsteinM K Smith
Feb 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·A B DeAngeloG R Olson
Nov 1, 1989·Teratology·M K SmithJ A Stober
Dec 1, 1982·Environmental Health Perspectives·J D JohnsonD S Millington
May 1, 1994·Reproductive Toxicology·R E LinderC J Dyer
Nov 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J E AndrewsJ M Rogers
Mar 1, 1983·Environmental Science & Technology·J W Miller, P C Uden

❮ Previous
Next ❯

Citations

Mar 11, 2000·Occupational and Environmental Medicine·M J NieuwenhuijsenP Elliott
Jul 11, 2007·TheScientificWorldJournal·Paige SniderSimon J Conway
Dec 19, 2009·Environmental Health Perspectives·Mark J NieuwenhuijsenMireille B Toledano
Jul 3, 2007·Water Research·Manuel J RodriguezDanielle Roy
Aug 31, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert G Ellis-Hutchings, Edward W Carney
Sep 15, 2010·Environmental and Molecular Mutagenesis·Michael J PlewaElizabeth D Wagner
Jun 16, 2010·Environmental Toxicology·Murali K MallelaTerry C Hrubec
Sep 16, 2009·Environmental and Molecular Mutagenesis·Mark G MuellnerMichael J Plewa
Mar 11, 2006·Reproductive Toxicology·E Sidney HunterNeil Chernoff
Nov 19, 2005·Reproductive Toxicology·E Sidney HunterNeil Chernoff
Nov 25, 2003·International Journal of Hygiene and Environmental Health·Andrey I EgorovTimothy E Ford
Jul 15, 2015·Environmental Science & Technology·Michael GonsiorPhilippe Schmitt-Kopplin
Jul 17, 1999·Toxicology and Applied Pharmacology·I R SchultzR J Bull
May 6, 2015·Environmental Science & Technology·Clara H JeongMichael J Plewa
Sep 7, 2001·Toxicology and Applied Pharmacology·I R Schultz, S R Sylvester
Jan 2, 2014·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Virender K SharmaThomas J McDonald
Aug 31, 2016·Reproductive Toxicology·Susan L MakrisMichael G Narotsky
Nov 12, 2016·Water Research·Rassil Sayess, David A Reckhow
Dec 31, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shakil A Saghir, Irvin R Schultz
Aug 13, 2002·International Journal of Toxicology·M S ChristianD M Creasy
Sep 22, 2011·International Journal of Toxicology·Shakil A SaghirIrvin R Schultz
Oct 13, 2017·Journal of Occupational and Environmental Medicine·John A KaufmanMichael G Narotsky
Jul 23, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Anthony B Firulli, Simon J Conway
Feb 9, 2002·Environmental Health Perspectives·Frank BovePerri Zeitz
Nov 16, 2018·Journal of Biochemical and Molecular Toxicology·Omar IssaFrederick E Williams
May 13, 2008·Rapid Communications in Mass Spectrometry : RCM·Benjamin P-Y Lau, Adam Becalski
Jul 15, 2005·American Journal of Epidemiology·Chad K PorterMark R Riddle
Sep 26, 2013·Journal of Occupational and Environmental Medicine·Zorimar Rivera-Núñez, J Michael Wright
Feb 27, 2015·Journal of Water and Health·Elisabet TeixidóJesús Gómez-Catalán
May 23, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hoffman B M LantumM W Anders
Mar 18, 2020·International Journal of Molecular Sciences·Andressa GonsioroskiJodi A Flaws

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.