Comparative effects of ionic and nonionic iodinated low-osmolar contrast media on platelet function with the PFA-100 (platelet function analyzer)

Investigative Radiology
A D'Anglemont De TassignyA C Corot

Abstract

This study was designed to (1) compare the effects of ionic (ioxaglate) and nonionic (iodixanol and iohexol) iodinated low-osmolar contrast media (CM) on platelet function in human whole blood by using the new PFA-100trade mark, a "platelet function analyzer"; (2) determine the animal species closest to human with regard to platelet reactivity to CM; and (3) evaluate which element of the ioxaglate solution supports this activity. For all studies, platelet adhesion and aggregation were measured using the PFA-100trade mark system with adenosine diphosphate-primed collagen membrane cartridges. Results are shown as the membrane closure time (MCT; the longer the MCT, the greater the antiaggregatory effect) and given as medians. Citrated whole-blood samples from six healthy volunteers were mixed for 1 minute with a 10% (vol/vol) solution of ioxaglate, iodixanol, or iohexol or their respective ionic and nonionic controls (isotonic saline and mannitol). The test solution/control solution ratio for the MCT was calculated for the blood of humans, guinea pigs, rabbits, dogs, and rats. Isotonic saline and iso-osmolar (280 mOsm/kg) and hyperosmolar (560 mOsm/kg) solutions of meglumine hydrochloride, meglumine ioxaglate (560 mOsm/kg), and so...Continue Reading

References

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Citations

Nov 26, 2002·Investigative Radiology·Val M Runge
Jul 24, 2012·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Tetsunori TasakiYasutaka Hoshi
Oct 16, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Lloyd W KleinUNKNOWN Interventional Committee of the Society for Cardiovascular Angiography and Interventions
Dec 17, 2016·Assay and Drug Development Technologies·Hermann A M Mucke
Nov 28, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Enrique EsplugasFrancisco Jara
Aug 13, 2002·Current Opinion in Hematology·Emmanuel J Favaloro
Sep 27, 2003·Acta Radiologica·W K Laskey, J Gellman

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