Comparative effects of ischemia and acute hypoxemia on muscle afferents from tibialis anterior in cats

Muscle & Nerve
F Lagier-TessonnierY Jammes

Abstract

Comparative effects of ischemia and acute hypoxemia (PaO2 = 24 mm Hg) were studied in anesthetized cats on afferents from the tibialis anterior limb muscle. Metaboreceptors (groups III and IV fibers) and mechanoreceptors were identified by their activation by an intraarterial injection of lactic acid (LA) or high-frequency vibrations (HFV) applied to the extremity of the muscle tendon, respectively. Ischemia and hypoxemia exerted opposite influences on the two categories of muscle afferents: they depressed the response of mechanoreceptors to HFV, but markedly enhanced the spontaneous tonic activity of metaboreceptors. The effects of hypoxemia were delayed but slightly greater and lasted longer during the recovery period than those exerted by ischemia. The inhibitory action on mechanoreceptors exerted by a reduced oxygen supply to muscle is interpreted as a result from local acidosis. Indeed, under normoxic conditions, a LA bolus injection during the HFV test also reduced the firing rate of these receptors.

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Citations

Jul 24, 2007·Experimental Brain Research·Patrick DecherchiYves Jammes
Oct 3, 2007·Pflügers Archiv : European journal of physiology·Mathieu CoulangeYves Jammes
Oct 11, 2008·Pflügers Archiv : European journal of physiology·Stéphane DelliauxYves Jammes
Sep 1, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·Y JammesM Badier
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·E DoussetY Jammes
Jun 27, 2009·High Altitude Medicine & Biology·Markus Amann, Bengt Kayser
Mar 21, 2012·High Altitude Medicine & Biology·Francis DegacheGregoire Millet
Jan 1, 1996·Archives of Physiology and Biochemistry·M C Zattara-Hartmann, Y Jammes
Jan 1, 1996·Archives of Physiology and Biochemistry·M C Zattara-Hartmann, Y Jammes
Nov 26, 2003·Muscle & Nerve·Nadège GosselinAlain Varray
Jul 14, 2010·Clinical Biomechanics·Yan-Ying JuHsin-Yi Kathy Cheng
Jul 20, 2007·American Journal of Human Biology : the Official Journal of the Human Biology Council·S M BaileyS Qui
Aug 31, 2006·Muscle & Nerve·Stéphane Delliaux, Yves Jammes
Aug 17, 2005·Neuroscience Letters·Kevin M PlineRobert W Grange
Mar 8, 2011·Annals of Physical and Rehabilitation Medicine·S Boyas, A Guével
Oct 23, 2001·The Journal of Orthopaedic and Sports Physical Therapy·L A HiemstraP J Fowler
Dec 18, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Anne HoussierePhilippe van de Borne
Nov 19, 2013·Medicine and Science in Sports and Exercise·John GoetschiusJoseph M Hart
Jan 28, 2020·High Altitude Medicine & Biology·Abdullah AlshukryMarion Montava
Oct 3, 2001·Physiological Reviews·S C Gandevia
Jan 18, 2020·Scientific Reports·Francis DegacheGrégoire P Millet
May 1, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Patrick Decherchi, Erick Dousset

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