Comparative Effects of Methylphenidate, Modafinil, and MDMA on Response Inhibition Neural Networks in Healthy Subjects

The International Journal of Neuropsychopharmacology
André SchmidtStefan Borgwardt

Abstract

Psychostimulants such as methylphenidate and modafinil are increasingly used by healthy people for cognitive enhancement purposes, whereas the acute effect of 3,4-methylenedioxymethamphetamine (ecstasy) on cognitive functioning in healthy subjects remains unclear. This study directly compared the acute effects of methylphenidate, modafinil, and 3,4-methylenedioxymethamphetamine on the neural mechanisms underlying response inhibition in healthy subjects. Using a double-blind, within-subject, placebo-controlled, cross-over design, methylphenidate, modafinil, and 3,4-methylenedioxymethamphetamine were administrated to 21 healthy subjects while performing a go/no-go event-related functional magnetic resonance imaging task to assess brain activation during motor response inhibition. Relative to placebo, methylphenidate and modafinil but not 3,4-methylenedioxymethamphetamine improved inhibitory performance. Methylphenidate significantly increased activation in the right middle frontal gyrus, middle/superior temporal gyrus, inferior parietal lobule, presupplementary motor area, and anterior cingulate cortex compared with placebo. Methylphenidate also induced significantly higher activation in the anterior cingulate cortex and presuppl...Continue Reading

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Citations

Dec 6, 2017·The International Journal of Neuropsychopharmacology·André SchmidtStefan Borgwardt
Oct 3, 2017·Psychological Medicine·A SchmidtS Borgwardt
Jan 18, 2020·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Ana Sousa, Ricardo Jorge Dinis-Oliveira
Jan 30, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jialin LiBenjamin Becker
Apr 11, 2018·The International Journal of Neuropsychopharmacology·Dominique VodovarMathieu Charvériat
Jan 4, 2019·Psychopharmacology·Kathryne Van HedgerHarriet de Wit
Jan 9, 2021·Translational Psychiatry·Alekhya MandaliValerie Voon
Jul 28, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Carl A RobertsCatharine Montgomery

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