Comparative effects of oral molsidomine and nifedipine on methylergometrine-induced coronary artery spasm

The American Journal of Cardiology
N DanchinF Cherrier

Abstract

Twelve consecutive patients (10 men and 2 women, mean +/- standard deviation age 49 +/- 9 years) with chest pain, angiographically normal coronary arteries and coronary artery spasm documented by methylergometrine testing received a single oral dose of molsidomine (4 mg) or nifedipine (10 mg) in a randomized, double-blind, crossover fashion at a 24-hour interval. Coronary artery spasm was documented during coronary angiography in 6 patients (left anterior descending artery, 3; right coronary artery, 2; left circumflex, 1). In the remaining 6 patients, coronary artery spasm was documented by a positive methylergometrine test performed at the bedside, which provoked ST-segment elevation in the inferior (n = 3), anterior (n = 1) or lateral (n = 2) leads. Ninety minutes after administration of the study medication, methylergometrine testing was performed at the bedside, using incremental doses of up to 0.4 mg of methylergometrine. After molsidomine, 10 patients (83%) had a negative and 2 had a positive test; after nifedipine, 9 patients (75%) had a negative and 3 a positive test. Only 1 patient had a methylergometrine test that remained positive after either molsidomine or nifedipine. Therefore, molsidomine appears as effective as ...Continue Reading

References

Oct 22, 1979·The American Journal of Cardiology·S GoldbergJ A Kastor
Jan 1, 1989·American Heart Journal·M PrevitaliJ A Salerno
Mar 1, 1985·American Heart Journal·J Ostrowski, K Resag
Mar 1, 1985·American Heart Journal·S WeberM Degeorges
Jul 1, 1985·American Heart Journal·C R ContiC J Pepine
Aug 1, 1983·Journal of the American College of Cardiology·C Bott-Silverman, F A Heupler
Dec 1, 1980·The American Journal of Cardiology·S J RosenthalJ S Schroeder
Apr 9, 1981·The New England Journal of Medicine·S M JohnsonL D Hillis
Jun 1, 1981·American Heart Journal·C J PepineC R Conti
Aug 1, 1983·Journal of the American College of Cardiology·D D WatersP Théroux
Jul 1, 1981·The American Journal of Cardiology·A J TiefenbrunnP A Ludbrook

Citations

Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·G Cirino
May 9, 2002·Expert Opinion on Investigational Drugs·I L Megson, D J Webb

Related Concepts

Coronary Artery Vasospasm
Sinus Node Artery
Double-Blind Method
Ergotrate
Molsidomin von ct
Fenigidin
Coronary Angiography

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.