PMID: 2568455Mar 1, 1989

Comparative effects of ouabain on isolated papillary muscle from tree shrews, guinea-pigs and rats

The Journal of Pharmacy and Pharmacology
T KogaK Sakai

Abstract

Inotropic effects of ouabain were investigated in the isolated papillary muscle preparations of the tree shrew (Tupaia glis), guinea-pigs and rats. In the guinea-pig and shrew papillary muscles, ouabain at concentrations of 10(-8) to 3 x 10(-7) M caused a concentration-dependent positive inotropic response in a similar magnitude, while in the rat, ouabain at concentrations of 10(-7) to 3 x 10(-6) M elicited negative inotropic one. Either phentolamine or pindolol in a concentration sufficient to block the alpha- and beta-adrenoceptors did not antagonize the positive inotropic effect of ouabain in the papillary muscle preparation of the shrews.

References

Dec 1, 1977·Circulation Research·L D HorwitzM Saito
Mar 16, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·P M StephenB H Marks
Nov 19, 1986·European Journal of Pharmacology·R KafiluddiE Seifen
Jun 1, 1968·The Bulletin of Mathematical Biophysics·G W Moore, M Goodman
Feb 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·W F Noyes
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Sep 23, 1966·Science·M Goodman

Citations

Jun 18, 2005·Journal of Pharmacological and Toxicological Methods·Daniela S HauserGuido Hanauer

Related Concepts

Cavia porcellus
Myocardial Contraction
Ouabain
Structure of Papillary Muscle
Z-Max
Visken
August Rats
Shrews

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