Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells

Agents and Actions
F De ClerckM Borgers

Abstract

Oxatomide inhibits the release of histamine from rat peritoneal mast cells in vitro induced by C 48/80, antigen, anti-IgE and ionophore A 23 187, without effect on non-specific release by n-decylamine. Its effect is concentration- and pH-dependent and decreases with increasing extracellular Ca2+-concentrations. Prolonged incubation does not enhance the inhibition, which is lost after one single wash-out. Aminophylline and isoproterenol are not potentiated by oxatomide. The present study points to an effect of oxatomide on a Ca2+-dependent process at the level of cell membrane common to antigen, C 48/80 and ionophore A 23 187.

References

Jan 1, 1978·International Archives of Allergy and Applied Immunology·M BorgersP A Janssen
May 24, 1975·Lancet·J F BatchelorJ E Tateson
Jan 1, 1975·International Archives of Allergy and Applied Immunology·B Diamant, S A Patkar
Aug 1, 1976·Biochemical Pharmacology·W KazimierczakC Maśliński
Aug 15, 1977·Biochimica Et Biophysica Acta·C M Fewtrell, B D Gomperts
Jan 1, 1978·International Archives of Allergy and Applied Immunology·H NagaiA H Sehon
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·F HirataF T Crews
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T IshizakaK Ishizaka
Jan 1, 1979·International Journal of Immunopharmacology·C W BiermanJ L Mongar
Mar 25, 1975·Biochimica Et Biophysica Acta·R H Michell
Jan 1, 1975·International Archives of Allergy and Applied Immunology·J C Foreman, B D Gomperts
Dec 1, 1978·Agents and Actions·F De ClerckF Awouters
Jun 1, 1975·Journal of Immunological Methods·R P Siraganian
Nov 1, 1972·The Journal of Clinical Investigation·E Gillespie, L M Lichtenstein
Jan 1, 1973·International Archives of Allergy and Applied Immunology·N S Ranadive, D H Ruben
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D B GoodmanC E Guthrow
Jan 1, 1974·International Archives of Allergy and Applied Immunology·W A TaylorI M Roitt
Jan 1, 1974·International Archives of Allergy and Applied Immunology·W A TaylorI M Roitt
Jan 1, 1980·International Archives of Allergy and Applied Immunology·N S Ranadive, N Dhanani
Jan 1, 1980·Current Medical Research and Opinion·J De CreeH Verhaegen
Nov 6, 1964·Medizinische Klinik·C HACKMANN

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.