PMID: 6167819Jul 1, 1981Paper

Comparative effects of prenalterol and dobutamine in a canine model of acute ischemic heart failure

Journal of Cardiovascular Pharmacology
P C KirlinB Lucchesi

Abstract

The hemodynamic effects of the inotropic agents prenalterol and dobutamine were compared in a canine model of acute ischemic heart failure following two-vessel coronary artery constriction. Intravenous infusions of both inotropic agents resulted in improvement of cardiac output, left ventricular maximum dP/dt, and contractile force in the nonischemic zone and in a decrease in systemic vascular resistance. No significant changes occurred in ischemic zone contractile force or left ventricular end-diastolic pressure following either inotropic agent compared to saline controls. Significant differences between the two inotropic agents consisted of prenalterol's markedly longer duration of action (hemodynamic half life of 3 hr after discontinuation compared to a value of 1.7 min after dobutamine discontinuation) and greater augmentation of cardiac output at high-dose dobutamine due to greater increases in heart rate. However, similar hemodynamic effects were noted with prenalterol and dobutamine at doses which increased nonischemic contractile force 50%. Both inotropic agents were associated with ventricular arrhythmias in the acute ischemic state. Implications regarding the use of prenalterol and dobutamine in clinical acute ischemi...Continue Reading

Citations

Sep 1, 1995·Progress in Cardiovascular Diseases·J E TisdaleB J Zarowitz
May 1, 1983·Clinical and Experimental Pharmacology & Physiology·A BranziB Magnani
Jun 1, 1982·Journal of Clinical and Hospital Pharmacy·M J KendallS Westerling

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