Comparative effects of sertraline, haloperidol or olanzapine treatments on ketamine-induced changes in mouse behaviours

Metabolic Brain Disease
Olakunle James OnaolapoAdejoke Yetunde Onaolapo

Abstract

Effects of sertraline, haloperidol or olanzapine administration on ketamine-induced behaviours in mice were examined. The aim was to ascertain the degree of reversal of such behaviours by sertraline, and compare its effectiveness to haloperidol and olanzapine. Ten-week old mice (N = 120) were equally divided into main groups; 1 (open-field, radial-arm maze and elevated plus maze {EPM} tests), and 2 (social interaction test). Mice in each main group were assigned into six groups of ten (n = 10) each. Group 1 received intraperitoneal (i.p) injection of vehicle, while groups 2-6 received i.p ketamine at 15 mg/kg daily for 10 days. From day 11 to 24, mice in group 1 (vehicle) were given distilled water (i.p at 2 ml/kg and oral at 10 ml/kg), group 2 (ketamine control) received daily i.p ketamine and oral distilled water; while animals in groups 3-6 received daily i.p. ketamine and oral haloperidol (4 mg/kg), olanzapine (2 mg/kg), or one of two doses of sertraline (SERT) (2.5 or 5 mg/kg), respectively. Treatments were administered daily, and behaviours assessed on days 11 and 24. Results showed that repeated ketamine administration caused hyperlocomotion, increased self-grooming, memory loss and social withdrawal. Administration of s...Continue Reading

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Citations

Feb 7, 2019·Behavioural Pharmacology·Solange BandieraRosane Gomez
Nov 19, 2019·Frontiers in Cellular and Infection Microbiology·Maiara Maria RomanelliAndre Gustavo Tempone
May 29, 2021·Frontiers in Psychiatry·Ridge G WestonBrendon O Watson

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