PMID: 12105116Jul 10, 2002

Comparative effects of substituted amphetamines (PMA, MDMA, and METH) on monoamines in rat caudate: a microdialysis study

Annals of the New York Academy of Sciences
B GoughSyed F Ali

Abstract

Paramethoxyamphetamine (PMA) is a methoxylated phenethylamine derivative that has been used illicitly in Australia since 1994. PMA is also becoming popular at rave parties in the United States. PMA raised concern when a series of fatalities resulted after its use in South Australia, where it was marketed as "ecstasy," which is the colloquial name for MDMA. In the present study, we evaluated the comparative neurotoxicity of substituted amphetamines in rats. Extracellular levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), serotonin (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) were assayed in the caudate of freely moving rats using microdialysis and HPLC-EC. Dialysates were assayed every 20 minutes for 4 hours after an intraperitoneal (i.p.) injection of PMA (2.5, 5, 10, 20 mg/kg), MDMA (10 and 20 mg/kg), or METH (2.5 mg/kg). METH produced a significant increase in extracellular DA (700%), and significant decreases in extracellular DOPAC and HVA (30% and 50%), with no detectable changes in either 5-HT or 5-HIAA. MDMA produced significant increases in DA (700% at 10 mg/kg and 950% at 20 mg/kg) and decreases in DOPAC (15% for both 10 and 20 mg/kg), and HVA (50% at 10 mg/kg and 35% at 20 mg/k...Continue Reading

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Citations

Jan 10, 2020·British Journal of Clinical Pharmacology·David Nutt
May 3, 2011·Expert Opinion on Drug Discovery·Altaf S DarveshCornelis J Van der Schyf
Sep 27, 2006·Neurotoxicity Research·Cesar A RomeroMario Herrera-Marschitz
Jul 14, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Vera Bubenikova-ValesovaRomana Slamberova
Aug 31, 2012·The International Journal of Neuropsychopharmacology·Michael J SeminerioRae R Matsumoto

Related Concepts

4-methoxyamphetamine, (S)-isomer
Thyramine
Amphetamines
Caudate Nucleus Structure
Intropin
Homovanillic Acid
Hydroxyindoleacetic Acid
Madrine
Hydroxytryptamine
3,4-Dihydroxyphenylacetic Acid, Monosodium Salt

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