PMID: 22338550Feb 18, 2012Paper

Comparative effects of zinc, selenium and vitamin E or their combination on carbohydrate metabolizing enzymes and oxidative stress in streptozotocin induced-diabetic rats

European Review for Medical and Pharmacological Sciences
H F Aly, M M Mantawy

Abstract

It is well documented that oxidative stress is a basic mechanism behind the development of diabetic state. The current study was undertaken to elucidate the hypoglycemic role of zinc, selenium and vitamin E and their mixture in comparison with the antidiabetic drug glibenclamide. Male Wistar rats weighing 250 +/- 50 g were made diabetic by injection with a single i.p. dose of streptozotocin (STZ) (65 mg/kg b. wt). Diabetic groups were simultaneously i.p. injected either with zinc chloride (ZnCI2) (5 mg/kg) or with selenium and vitamin E (1.5 mg/kg as sodium selenite and vitamin E 1000 mg/kg) or with zinc, selenium and vitamin E each element i.p. injected according to its corresponding therapeutic dose daily for one month. Another group was orally treated daily with glibenclamide drug (5 mg/kg) for one month. Blood and tissue samples were collected at day 3 post STZ injection (from one group serum glucose level significantly elevated < or = 300, p < or = 0.05) and at day 30 post-treatment in other groups. Liver function, nitric oxide (NO), malondialdehyde (MDA) and phosphoenol pyruvate carboxykinase (PEPCK) were significantly increased, while superoxide dismutase (SOD), reduced glutathione (GSH), total protein, lactate dehydroge...Continue Reading

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